Cyclopropanamine, 1-(trifluoromethyl)- (9CI)

Base Information

• Chemical Name: Cyclopropanamine, 1-(trifluoromethyl)- (9CI)
• CAS No.: 112738-68-8
• Molecular Formula: C₄H₆F₃N
• Molecular Weight: 125.094
• Mol file: 112738-68-8.mol

Synonyms:1-(Trifluoromethyl)cyclopropylamine;

Chemical Property of Cyclopropanamine, 1-(trifluoromethyl)- (9CI)

Chemical Property:

• Boiling Point: 48.554 °C at 760 mmHg
• PKA: 4.59±0.20(Predicted)
• Flash Point: -6.494 °C
• PSA: 26.02000
• Density: 1.355 g/cm³
• LogP: 1.74030

Purity/Quality:

98%min ^*data from raw suppliers

1-Trifluoromethyl-1-cyclopropylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(Trifluoromethyl-1-cyclopropylamine is used in preparation of tricyclic pyrazole derivatives useful for the treatment of diseases mediated by the cannabinoid CB2 receptor.

Technology Process of Cyclopropanamine, 1-(trifluoromethyl)- (9CI)

There total 1 articles about Cyclopropanamine, 1-(trifluoromethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (1-(trifluoromethyl)cyclopropyl)carbamate (902494-31-9) → 1-(trifluoromethyl)cyclopropan-1-amine (112738-68-8)

Guidance literature:

With hydrogenchloride; at 100 ℃; for 2h; Inert atmosphere;

Reference yield: 40.0%

1-(trifluoromethyl)cyclopropan-1-amine (112738-68-8) + 3-((5-fluoro-6-methylpyridin-2-yl)carbamoyl)-4-methoxybenzene-1-sulfonyl chloride → (S)-N-(5-fluoro-6-methylpyridin-2-yl)-2-methoxy-5-(N-(1-(trifluoromethyl)cyclopropyl)sulfamoyl)benzamide

Guidance literature:

With pyridine; at 0 - 20 ℃;

Reference yield: 18.0%

1-(trifluoromethyl)cyclopropan-1-amine (112738-68-8) + C14H9ClFNO5 → C18H13ClF4N2O4

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

upstream raw materials:

tert-butyl (1-(trifluoromethyl)cyclopropyl)carbamate

Downstream raw materials:

C₁₈H₁₆F₄N₂O₃S

Refernces