Technology Process of (5S)-7-[(1R)-1-phenylethyl]-1,7-diazaspiro[4.4]nonan-6-one
There total 6 articles about (5S)-7-[(1R)-1-phenylethyl]-1,7-diazaspiro[4.4]nonan-6-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: methanol / 1 h / 20 °C
1.2: magnesium sulfate / methanol / 4 h / 20 °C
1.3: NaBH4 / methanol / 1 h / 20 °C
2.1: sodium amide / toluene / 24 h / Heating
3.1: 73 percent / TFA / CH2Cl2 / 20 °C
With
sodium amide; trifluoroacetic acid;
In
methanol; dichloromethane; toluene;
DOI:10.1016/j.tet.2007.06.050
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium amide / toluene / 24 h / Heating
2: 73 percent / TFA / CH2Cl2 / 20 °C
With
sodium amide; trifluoroacetic acid;
In
dichloromethane; toluene;
DOI:10.1016/j.tet.2007.06.050
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 74 percent / DMAP; Et3N / CH2Cl2 / 20 °C
2.1: LiHMDS / tetrahydrofuran / -78 °C
2.2: 80 percent / tetrahydrofuran / 20 °C
3.1: 74 percent / OsO4; NaIO4; H2O / tetrahydrofuran / 20 °C
4.1: methanol / 1 h / 20 °C
4.2: magnesium sulfate / methanol / 4 h / 20 °C
4.3: NaBH4 / methanol / 1 h / 20 °C
5.1: sodium amide / toluene / 24 h / Heating
6.1: 73 percent / TFA / CH2Cl2 / 20 °C
With
dmap; sodium periodate; osmium(VIII) oxide; water; sodium amide; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1016/j.tet.2007.06.050