(3-endo)-3-[8-(5-hexen-1-yl)-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile

Base Information

Chemical Name:(3-endo)-3-[8-(5-hexen-1-yl)-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile
CAS No.:852435-97-3
Molecular Formula:C₂₈H₃₄N₂
Molecular Weight:398.591
Hs Code.:

Synonyms:(3-endo)-3-[8-(5-hexen-1-yl)-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile

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Chemical Property of (3-endo)-3-[8-(5-hexen-1-yl)-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile

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Technology Process of (3-endo)-3-[8-(5-hexen-1-yl)-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile

There total 6 articles about (3-endo)-3-[8-(5-hexen-1-yl)-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: (3-endo)-3-(8-azabicyclo[3.2.1]oct-3-yl)-2,2-diphenylpropanenitrile trifluoroacetate

: 2695-47-8
6-Bromo-1-hexene

: 852435-97-3
(3-endo)-3-[8-(5-hexen-1-yl)-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile

Guidance literature:: With potassium carbonate; In acetonitrile; for 16h; Heating / reflux;

Reference yield:

: 852460-98-1
[(3-endo)-8-(phenylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]methanol

: 852435-97-3
(3-endo)-3-[8-(5-hexen-1-yl)-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; hydrogen / palladium hydroxide on carbon / ethanol; water / 66 h / 20 °C / 2844.39 Torr

1.2: 20 °C

2.1: triethylamine / dichloromethane / 16 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 1.17 h / 220 °C / Microwave

4.1: potassium carbonate / acetonitrile / 16 h / Heating / reflux

With hydrogenchloride; hydrogen; sodium hydride; potassium carbonate; triethylamine; palladium hydroxide on carbon; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 273376-39-9
tert-butyl rel-(1R,3r,5S)-3-(hydroxymethyl)-8-azabicyclo[3.2.1]octane-8-carboxylate

: 852435-97-3
(3-endo)-3-[8-(5-hexen-1-yl)-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 16 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 1.17 h / 220 °C / Microwave

3: potassium carbonate / acetonitrile / 16 h / Heating / reflux

With sodium hydride; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;