Boc-Phe-oxymethoxycarbonyl-4-(aminomethyl)benzoyl-β-Ala-Asp(OBzl)-OTce

Base Information

Chemical Name:Boc-Phe-oxymethoxycarbonyl-4-(aminomethyl)benzoyl-β-Ala-Asp(OBzl)-OTce
CAS No.:566180-31-2
Molecular Formula:C₄₀H₄₅Cl₃N₄O₁₂
Molecular Weight:880.176
Hs Code.:

Synonyms:Boc-Phe-oxymethoxycarbonyl-4-(aminomethyl)benzoyl-β-Ala-Asp(OBzl)-OTce

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Chemical Property of Boc-Phe-oxymethoxycarbonyl-4-(aminomethyl)benzoyl-β-Ala-Asp(OBzl)-OTce

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Technology Process of Boc-Phe-oxymethoxycarbonyl-4-(aminomethyl)benzoyl-β-Ala-Asp(OBzl)-OTce

There total 7 articles about Boc-Phe-oxymethoxycarbonyl-4-(aminomethyl)benzoyl-β-Ala-Asp(OBzl)-OTce which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: (S)-2-Amino-succinic acid 4-benzyl ester 1-(2,2,2-trichloro-ethyl) ester; compound with trifluoro-acetic acid

: 566180-39-0
Boc-Phe-oxymethoxycarbonyl-4-(aminomethyl)benzoyl-β-Ala-OH

: 566180-31-2
Boc-Phe-oxymethoxycarbonyl-4-(aminomethyl)benzoyl-β-Ala-Asp(OBzl)-OTce

Guidance literature:: Boc-Phe-oxymethoxycarbonyl-4-(aminomethyl)benzoyl-β-Ala-OH; With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 0.0166667h; cooling;

(S)-2-Amino-succinic acid 4-benzyl ester 1-(2,2,2-trichloro-ethyl) ester; compound with trifluoro-acetic acid; In dichloromethane;
DOI:10.1016/S0040-4020(03)00333-8

Reference yield: 71.0%

: [N-(t-butyloxycarbonyl)phenylalanyloxy]methyl p-nitrophenyl carbonate

: 4-(aminomethyl)benzoyl-β-Ala-Asp(OBzl)-OTce trifluoroacetate

: 566180-31-2
Boc-Phe-oxymethoxycarbonyl-4-(aminomethyl)benzoyl-β-Ala-Asp(OBzl)-OTce

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/S0040-4020(03)00333-8

Reference yield:

: 33233-67-9
4-(tert-Butoxycarbonylaminomethyl)benzoic acid

: 566180-31-2
Boc-Phe-oxymethoxycarbonyl-4-(aminomethyl)benzoyl-β-Ala-Asp(OBzl)-OTce

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; N-methylmorpholine / CH₂Cl₂ / 0.02 h / 0 - 2 °C

1.2: 94 percent / CH₂Cl₂ / 24 h / 20 °C

2.1: 87 percent / trifluoroacetic acid / CH₂Cl₂

3.1: 77 percent / TEA / CH₂Cl₂ / 0 - 20 °C

4.1: 72 percent / dimethylformamide / 0 - 25 °C

5.1: 85 percent / H₂ / Pd/C / methanol / 24 h

6.1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; N-methylmorpholine / CH₂Cl₂ / 0.02 h / cooling

6.2: 94 percent / CH₂Cl₂

With 4-methyl-morpholine; TEA; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(03)00333-8