C₂₁H₃₀O₃

Base Information

• Chemical Name: C₂₁H₃₀O₃
• CAS No.: 1354005-95-0
• Molecular Formula: C₂₁H₃₀O₃
• Molecular Weight: 330.467
• Mol file: 1354005-95-0.mol

Synonyms:C₂₁H₃₀O₃

Chemical Property of C₂₁H₃₀O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₃₀O₃

There total 11 articles about C₂₁H₃₀O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

C27H44O3Si (1354005-85-8) → C21H30O3 (1354005-95-0)

Guidance literature:

With pyridine; pyridine hydrogenfluoride; In tetrahydrofuran; at 40 ℃; for 3h;

DOI:10.1016/j.tetlet.2011.10.151

Reference yield:

C21H30O3 → C21H30O3 (1354005-95-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: Dess-Martin periodane / dichloromethane / 1 h / 0 °C

2.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 6 h / -40 °C

3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / 4 h / 40 °C

3.2: 12 h / -78 - 0 °C

4.1: 2,6-dimethylpyridine / dichloromethane / 0.17 h / 20 °C

5.1: palladium diacetate; triethylamine; tris-(o-tolyl)phosphine / water; acetonitrile / 1.5 h / 80 °C

6.1: pyridine; pyridine hydrogenfluoride / tetrahydrofuran / 3 h / 40 °C

With pyridine; 2,6-dimethylpyridine; borane-THF; palladium diacetate; Dess-Martin periodane; pyridine hydrogenfluoride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; tris-(o-tolyl)phosphine; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; dichloromethane; water; acetonitrile; 5.1: Heck reaction;

DOI:10.1016/j.tetlet.2011.10.151

Reference yield:

C16H24O3 (1354005-88-1) → C21H30O3 (1354005-95-0)

Guidance literature:

Multi-step reaction with 9 steps

1.1: mercury(II) diacetate / 36 h / Reflux

2.1: methylaluminium bis(4-bromo-2,6-di-tert.-butylphenoxide) / dichloromethane / 0.25 h / -78 °C

3.1: n-butyllithium / tetrahydrofuran

3.2: 2 h / -78 °C

4.1: Dess-Martin periodane / dichloromethane / 1 h / 0 °C

5.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 6 h / -40 °C

6.1: sodium bis(2-methoxyethoxy)aluminium dihydride / 4 h / 40 °C

6.2: 12 h / -78 - 0 °C

7.1: 2,6-dimethylpyridine / dichloromethane / 0.17 h / 20 °C

8.1: palladium diacetate; triethylamine; tris-(o-tolyl)phosphine / water; acetonitrile / 1.5 h / 80 °C

9.1: pyridine; pyridine hydrogenfluoride / tetrahydrofuran / 3 h / 40 °C

With pyridine; 2,6-dimethylpyridine; n-butyllithium; borane-THF; mercury(II) diacetate; palladium diacetate; Dess-Martin periodane; pyridine hydrogenfluoride; methylaluminium bis(4-bromo-2,6-di-tert.-butylphenoxide); triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; tris-(o-tolyl)phosphine; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; dichloromethane; water; acetonitrile; 2.1: Claisen rearrangement / 8.1: Heck reaction;

DOI:10.1016/j.tetlet.2011.10.151

upstream raw materials:

C₂₇H₄₄O₃Si

C₁₆H₂₄O₃

C₁₈H₂₆O₃

(R)-3-((4-methoxybenzyl)oxy)-1-butanal

Downstream raw materials:

C₂₁H₂₈O₃

(6R,7E,9R)-9-Hydroxy-megastigma-4,7-dien-3-ons