(S)-4-(3-{(2S,3S)-3-Formyl-7-[3-(2-formyl-oxazol-5-yl)-1-methoxymethyl-1H-indol-4-yl]-2-methoxycarbonyl-2,3-dihydro-benzofuran-3-yl}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Base Information

• Chemical Name: (S)-4-(3-{(2S,3S)-3-Formyl-7-[3-(2-formyl-oxazol-5-yl)-1-methoxymethyl-1H-indol-4-yl]-2-methoxycarbonyl-2,3-dihydro-benzofuran-3-yl}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester
• CAS No.: 760980-30-1
• Molecular Formula: C₄₆H₄₃N₃O₁₁
• Molecular Weight: 813.861

Synonyms:(S)-4-(3-{(2S,3S)-3-Formyl-7-[3-(2-formyl-oxazol-5-yl)-1-methoxymethyl-1H-indol-4-yl]-2-methoxycarbonyl-2,3-dihydro-benzofuran-3-yl}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Chemical Property of (S)-4-(3-{(2S,3S)-3-Formyl-7-[3-(2-formyl-oxazol-5-yl)-1-methoxymethyl-1H-indol-4-yl]-2-methoxycarbonyl-2,3-dihydro-benzofuran-3-yl}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-(3-{(2S,3S)-3-Formyl-7-[3-(2-formyl-oxazol-5-yl)-1-methoxymethyl-1H-indol-4-yl]-2-methoxycarbonyl-2,3-dihydro-benzofuran-3-yl}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

There total 12 articles about (S)-4-(3-{(2S,3S)-3-Formyl-7-[3-(2-formyl-oxazol-5-yl)-1-methoxymethyl-1H-indol-4-yl]-2-methoxycarbonyl-2,3-dihydro-benzofuran-3-yl}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(S)-4-(3-{(2S,3R)-3-Hydroxymethyl-7-[3-(2-hydroxymethyl-oxazol-5-yl)-1-methoxymethyl-1H-indol-4-yl]-2-methoxycarbonyl-2,3-dihydro-benzofuran-3-yl}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester (760980-28-7) → (S)-4-(3-{(2S,3S)-3-Formyl-7-[3-(2-formyl-oxazol-5-yl)-1-methoxymethyl-1H-indol-4-yl]-2-methoxycarbonyl-2,3-dihydro-benzofuran-3-yl}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester (760980-30-1)

Guidance literature:

With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 25 ℃; for 1h;

DOI:10.1021/ja040091q

Reference yield:

4-bromo-3-[2-(tert-butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-1-methoxymethyl-1H-indole (405519-78-0) → (S)-4-(3-{(2S,3S)-3-Formyl-7-[3-(2-formyl-oxazol-5-yl)-1-methoxymethyl-1H-indol-4-yl]-2-methoxycarbonyl-2,3-dihydro-benzofuran-3-yl}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester (760980-30-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 92 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.17 h / 0 °C

2: 93 percent / Et₃N / CH₂Cl₂ / 0.33 h / 0 °C

3: 83 percent / Pd(diphenylphosphinoferrocene)Cl₂*CH₂Cl₂; K₂CO₃ / 1,2-dimethoxy-ethane / 12 h / Heating

4: 93 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.33 h / 25 °C

5: 87 percent / Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂ / 1 h / 25 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 3: Suzuki coupling;

DOI:10.1021/ja040091q

Reference yield:

[5-(4-bromo-1-methoxymethyl-1H-indol-3-yl)-oxazol-2-yl]-methanol (760979-81-5) → (S)-4-(3-{(2S,3S)-3-Formyl-7-[3-(2-formyl-oxazol-5-yl)-1-methoxymethyl-1H-indol-4-yl]-2-methoxycarbonyl-2,3-dihydro-benzofuran-3-yl}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester (760980-30-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 93 percent / Et₃N / CH₂Cl₂ / 0.33 h / 0 °C

2: 83 percent / Pd(diphenylphosphinoferrocene)Cl₂*CH₂Cl₂; K₂CO₃ / 1,2-dimethoxy-ethane / 12 h / Heating

3: 93 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.33 h / 25 °C

4: 87 percent / Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂ / 1 h / 25 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 2: Suzuki coupling;

DOI:10.1021/ja040091q

upstream raw materials:

(S)-4-(3-{(2S,3R)-3-Hydroxymethyl-7-[3-(2-hydroxymethyl-oxazol-5-yl)-1-methoxymethyl-1H-indol-4-yl]-2-methoxycarbonyl-2,3-dihydro-benzofuran-3-yl}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

4-bromo-3-[2-(tert-butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-1-methoxymethyl-1H-indole

[5-(4-bromo-1-methoxymethyl-1H-indol-3-yl)-oxazol-2-yl]-methanol

4-bromo-3-[2-(tert-butyl-dimethyl-silanyloxymethyl)-oxazol-5-yl]-1-methoxymethyl-1H-indole

Downstream raw materials:

C₅₆H₆₃N₅O₁₃

C₆₆H₆₅N₅O₁₃

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 760980-30-1 (S)-4-(3-{(2S,3S)-3-Formyl-7-[3-(2-formyl-oxazol-5-yl)-1-methoxymethyl-1H-indol-4-yl]-2-methoxycarbonyl-2,3-dihydro-benzofuran-3-yl}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send