4-(7,7,10,10-Tetramethyl-7,8,9,10-tetrahydro-5H-13-aza-benzo[4,5]cyclohepta[1,2-b]naphthalen-12-yl)-benzoic acid methyl ester

Base Information

Chemical Name:4-(7,7,10,10-Tetramethyl-7,8,9,10-tetrahydro-5H-13-aza-benzo[4,5]cyclohepta[1,2-b]naphthalen-12-yl)-benzoic acid methyl ester
CAS No.:188845-43-4
Molecular Formula:C₃₀H₃₁NO₂
Molecular Weight:437.582
Hs Code.:

Synonyms:4-(7,7,10,10-Tetramethyl-7,8,9,10-tetrahydro-5H-13-aza-benzo[4,5]cyclohepta[1,2-b]naphthalen-12-yl)-benzoic acid methyl ester

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Chemical Property of 4-(7,7,10,10-Tetramethyl-7,8,9,10-tetrahydro-5H-13-aza-benzo[4,5]cyclohepta[1,2-b]naphthalen-12-yl)-benzoic acid methyl ester

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Technology Process of 4-(7,7,10,10-Tetramethyl-7,8,9,10-tetrahydro-5H-13-aza-benzo[4,5]cyclohepta[1,2-b]naphthalen-12-yl)-benzoic acid methyl ester

There total 17 articles about 4-(7,7,10,10-Tetramethyl-7,8,9,10-tetrahydro-5H-13-aza-benzo[4,5]cyclohepta[1,2-b]naphthalen-12-yl)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 188845-42-3
N-[2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-phenyl]-terephthalamic acid methyl ester

: 188845-43-4
4-(7,7,10,10-Tetramethyl-7,8,9,10-tetrahydro-5H-13-aza-benzo[4,5]cyclohepta[1,2-b]naphthalen-12-yl)-benzoic acid methyl ester

Guidance literature:: With PPA; at 110 ℃; for 0.75h;
DOI:10.1021/jm9704309

Reference yield:

: C₂₂H₂₄ClN

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 188845-43-4
4-(7,7,10,10-Tetramethyl-7,8,9,10-tetrahydro-5H-13-aza-benzo[4,5]cyclohepta[1,2-b]naphthalen-12-yl)-benzoic acid methyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 90 ℃; for 4h;
DOI:10.1002/anie.202007799

Reference yield:

: 22824-31-3
5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ol

: 188845-43-4
4-(7,7,10,10-Tetramethyl-7,8,9,10-tetrahydro-5H-13-aza-benzo[4,5]cyclohepta[1,2-b]naphthalen-12-yl)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: magnesium chloride; triethylamine / tetrahydrofuran / 0.17 h

1.2: 75 °C

2.1: pyridine / dichloromethane / 3 h / 0 - 20 °C

3.1: palladium diacetate; 1,4-di(diphenylphosphino)-butane; potassium carbonate / 1,4-dioxane / 100 °C / Inert atmosphere

4.1: trifluoroacetic acid / 5 h / Reflux

5.1: trichlorophosphate; N,N-dimethyl-aniline / 24 h / Reflux

6.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 4 h / 90 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; sodium carbonate; potassium carbonate; N,N-dimethyl-aniline; triethylamine; 1,4-di(diphenylphosphino)-butane; trifluoroacetic acid; magnesium chloride; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water;
DOI:10.1002/anie.202007799