4-{1-[(E)-1-Benzylcarbamoyl-3,3-diethyl-4-oxo-azetidin-2-yloxyimino]-ethyl}-benzoic acid benzhydryl ester

Base Information

Chemical Name:4-{1-[(E)-1-Benzylcarbamoyl-3,3-diethyl-4-oxo-azetidin-2-yloxyimino]-ethyl}-benzoic acid benzhydryl ester
CAS No.:266679-75-8
Molecular Formula:C₃₇H₃₇N₃O₅
Molecular Weight:603.718
Hs Code.:

Synonyms:4-{1-[(E)-1-Benzylcarbamoyl-3,3-diethyl-4-oxo-azetidin-2-yloxyimino]-ethyl}-benzoic acid benzhydryl ester

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Chemical Property of 4-{1-[(E)-1-Benzylcarbamoyl-3,3-diethyl-4-oxo-azetidin-2-yloxyimino]-ethyl}-benzoic acid benzhydryl ester

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Technology Process of 4-{1-[(E)-1-Benzylcarbamoyl-3,3-diethyl-4-oxo-azetidin-2-yloxyimino]-ethyl}-benzoic acid benzhydryl ester

There total 6 articles about 4-{1-[(E)-1-Benzylcarbamoyl-3,3-diethyl-4-oxo-azetidin-2-yloxyimino]-ethyl}-benzoic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 3173-56-6
benzyl isothiocyanate

: 266679-72-5
4-{1-[(E)-3,3-Diethyl-4-oxo-azetidin-2-yloxyimino]-ethyl}-benzoic acid benzhydryl ester

: 266679-75-8
4-{1-[(E)-1-Benzylcarbamoyl-3,3-diethyl-4-oxo-azetidin-2-yloxyimino]-ethyl}-benzoic acid benzhydryl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/S0223-5234(00)00111-2

Reference yield:

: 586-89-0
4-acetyl-benzoic acid

: 266679-75-8
4-{1-[(E)-1-Benzylcarbamoyl-3,3-diethyl-4-oxo-azetidin-2-yloxyimino]-ethyl}-benzoic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 41 percent / CHCl₃; dimethylformamide / 20 °C

2: 71 percent / K₂CO₃; NH₂OH*HCl / tetrahydrofuran; H₂O / 24 h / 20 °C

3: 43 percent / aq. NaOH / acetone / 0.67 h / 20 °C

4: 83 percent / Et₃N; 4-dimethylaminopyridine / CH₂Cl₂ / 24 h / 20 °C

With dmap; sodium hydroxide; hydroxylamine hydrochloride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone; 1: Esterification / 2: Condensation / 3: Substitution / 4: Addition;
DOI:10.1016/S0223-5234(00)00111-2

Reference yield:

: 126997-07-7
3,3-diethyl-4-acetyloxy-azetidin-2-one

: 266679-75-8
4-{1-[(E)-1-Benzylcarbamoyl-3,3-diethyl-4-oxo-azetidin-2-yloxyimino]-ethyl}-benzoic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / aq. NaOH / acetone / 0.67 h / 20 °C

2: 83 percent / Et₃N; 4-dimethylaminopyridine / CH₂Cl₂ / 24 h / 20 °C

With dmap; sodium hydroxide; triethylamine; In dichloromethane; acetone; 1: Substitution / 2: Addition;
DOI:10.1016/S0223-5234(00)00111-2