5-Ethyl-2-[4-[2-(4-methanesulfonylphenoxymethyl)pyridin-5-yl]piperidin-1-yl]pyrimidine

Base Information

Chemical Name:5-Ethyl-2-[4-[2-(4-methanesulfonylphenoxymethyl)pyridin-5-yl]piperidin-1-yl]pyrimidine
CAS No.:1206968-17-3
Molecular Formula:C₂₄H₂₈N₄O₃S
Molecular Weight:452.577
Hs Code.:

Synonyms:5-Ethyl-2-[4-[2-(4-methanesulfonylphenoxymethyl)pyridin-5-yl]piperidin-1-yl]pyrimidine

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Chemical Property of 5-Ethyl-2-[4-[2-(4-methanesulfonylphenoxymethyl)pyridin-5-yl]piperidin-1-yl]pyrimidine

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Technology Process of 5-Ethyl-2-[4-[2-(4-methanesulfonylphenoxymethyl)pyridin-5-yl]piperidin-1-yl]pyrimidine

There total 6 articles about 5-Ethyl-2-[4-[2-(4-methanesulfonylphenoxymethyl)pyridin-5-yl]piperidin-1-yl]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 850197-55-6
5-ethyl-2-bromopyrimidine

: 1206967-70-5
tert-butyl 4-[2-(4-methanesulfonylphenoxymethyl)-pyridin-5-yl]piperidine-1-carboxylate

: 1206968-17-3
5-Ethyl-2-[4-[2-(4-methanesulfonylphenoxymethyl)pyridin-5-yl]piperidin-1-yl]pyrimidine

Guidance literature:: tert-butyl 4-[2-(4-methanesulfonylphenoxymethyl)-pyridin-5-yl]piperidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

5-ethyl-2-bromopyrimidine; With potassium carbonate; In acetonitrile; at 80 ℃; for 18h;

Reference yield:

: 286961-15-7
benzyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1 (2H)-pyridinecarboxylate

: 1206968-17-3
5-Ethyl-2-[4-[2-(4-methanesulfonylphenoxymethyl)pyridin-5-yl]piperidin-1-yl]pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; tetrahydrofuran / 2.5 h / 90 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

3.1: triethylamine / water; tetrahydrofuran / 0.17 h / 20 °C

4.1: triethylamine / chloroform / 3 h / 20 °C / Cooling with ice; Inert atmosphere

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.42 h / Cooling with ice; Inert atmosphere

5.2: 20 °C / Reflux

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.2: 18 h / 80 °C

With hydrogen; sodium hydride; caesium carbonate; triethylamine; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 88139-91-7
(5-bromopyridin-2-yl)methanol

: 1206968-17-3
5-Ethyl-2-[4-[2-(4-methanesulfonylphenoxymethyl)pyridin-5-yl]piperidin-1-yl]pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; tetrahydrofuran / 2.5 h / 90 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

3.1: triethylamine / water; tetrahydrofuran / 0.17 h / 20 °C

4.1: triethylamine / chloroform / 3 h / 20 °C / Cooling with ice; Inert atmosphere

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.42 h / Cooling with ice; Inert atmosphere

5.2: 20 °C / Reflux

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.2: 18 h / 80 °C

With hydrogen; sodium hydride; caesium carbonate; triethylamine; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; mineral oil;