1-(3-cyanophenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea

Base Information

• Chemical Name: 1-(3-cyanophenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea
• CAS No.: 1376770-26-1
• Molecular Formula: C₂₅H₁₇F₃N₆S
• Molecular Weight: 490.511

Synonyms:1-(3-cyanophenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea

Chemical Property of 1-(3-cyanophenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea

Chemical Property:

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Technology Process of 1-(3-cyanophenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea

There total 4 articles about 1-(3-cyanophenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

6-(4-aminophenyl)-N-(3-(trifluoromethyl)phenyl)pyrimidin-4-amine (1376770-17-0) + 3-cyanophenyl isothiocyanate (3125-78-8) → 1-(3-cyanophenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea (1376770-26-1)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmcl.2012.03.092

Reference yield:

4-chloro-6-(4-nitrophenyl)pyrimidine (954221-91-1) → 1-(3-cyanophenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea (1376770-26-1)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / water; isopropyl alcohol / 0.33 h / 100 °C / Microwave irradiation

2: tin(ll) chloride / ethyl acetate / 12 h / 20 °C

3: tetrahydrofuran / 20 °C

With hydrogenchloride; tin(ll) chloride; In tetrahydrofuran; water; ethyl acetate; isopropyl alcohol;

DOI:10.1016/j.bmcl.2012.03.092

Reference yield:

3-trifluoromethylaniline (98-16-8) → 1-(3-cyanophenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea (1376770-26-1)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / water; isopropyl alcohol / 0.33 h / 100 °C / Microwave irradiation

2: tin(ll) chloride / ethyl acetate / 12 h / 20 °C

3: tetrahydrofuran / 20 °C

With hydrogenchloride; tin(ll) chloride; In tetrahydrofuran; water; ethyl acetate; isopropyl alcohol;

DOI:10.1016/j.bmcl.2012.03.092

upstream raw materials:

4-chloro-6-(4-nitrophenyl)pyrimidine

6-(4-aminophenyl)-N-(3-(trifluoromethyl)phenyl)pyrimidin-4-amine

3-cyanophenyl isothiocyanate

3-trifluoromethylaniline

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