4-(6-[3-(aminomethyl)phenyl]-1-ethyl-4-{1-[tris(1-methylethyl)silyl]-1H-pyrrol-3-yl}-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine

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Chemical Name:4-(6-[3-(aminomethyl)phenyl]-1-ethyl-4-{1-[tris(1-methylethyl)silyl]-1H-pyrrol-3-yl}-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine
CAS No.:913642-18-9
Molecular Formula:C₃₀H₄₀N₈OSi
Molecular Weight:556.786
Hs Code.:

Synonyms:4-(6-[3-(aminomethyl)phenyl]-1-ethyl-4-{1-[tris(1-methylethyl)silyl]-1H-pyrrol-3-yl}-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine

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Chemical Property of 4-(6-[3-(aminomethyl)phenyl]-1-ethyl-4-{1-[tris(1-methylethyl)silyl]-1H-pyrrol-3-yl}-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine

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Technology Process of 4-(6-[3-(aminomethyl)phenyl]-1-ethyl-4-{1-[tris(1-methylethyl)silyl]-1H-pyrrol-3-yl}-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine

There total 7 articles about 4-(6-[3-(aminomethyl)phenyl]-1-ethyl-4-{1-[tris(1-methylethyl)silyl]-1H-pyrrol-3-yl}-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 4-{6-[3-(aminomethyl)phenyl]-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl}-1,2,5-oxadiazol-3-amine

: 138900-55-7
1-(triisopropylsilyl)-1H-pyrrole-3-boronic acid

: 913642-18-9
4-(6-[3-(aminomethyl)phenyl]-1-ethyl-4-{1-[tris(1-methylethyl)silyl]-1H-pyrrol-3-yl}-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 70 ℃; for 12h;

Reference yield:

: 913642-06-5
4-(6-bromo-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine

: 913642-18-9
4-(6-[3-(aminomethyl)phenyl]-1-ethyl-4-{1-[tris(1-methylethyl)silyl]-1H-pyrrol-3-yl}-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / 70 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / 70 °C

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water;

Reference yield:

: 913642-07-6
2-bromo-N-ethyl-5-nitro-4-pyridinamine

: 913642-18-9
4-(6-[3-(aminomethyl)phenyl]-1-ethyl-4-{1-[tris(1-methylethyl)silyl]-1H-pyrrol-3-yl}-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride; tin(ll) chloride / water / 0.75 h / 90 °C

1.2: pH ~ 10

2.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: acetic acid / 24 h / 100 °C

4.1: acetic acid; sodium nitrite / 16 h / 20 °C

5.1: hydroxylamine; triethylamine / 1,4-dioxane / 16 h / 100 °C

6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / 70 °C

7.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / 70 °C

With 4-methyl-morpholine; hydrogenchloride; hydroxylamine; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tin(ll) chloride; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide;