(1’S,3’S,7’R,8a’R)-3’-(formyl)-7’-(methoxycarbonylmethyl)-5’-oxo-1-(phenylsulfonyl) spiro[indoline-3,1’-indolizidine]

Base Information

Chemical Name:(1’S,3’S,7’R,8a’R)-3’-(formyl)-7’-(methoxycarbonylmethyl)-5’-oxo-1-(phenylsulfonyl) spiro[indoline-3,1’-indolizidine]
CAS No.:1423035-82-8
Molecular Formula:C₂₅H₂₆N₂O₆S
Molecular Weight:482.557
Hs Code.:

Synonyms:(1’S,3’S,7’R,8a’R)-3’-(formyl)-7’-(methoxycarbonylmethyl)-5’-oxo-1-(phenylsulfonyl) spiro[indoline-3,1’-indolizidine]

Suppliers and Price of (1’S,3’S,7’R,8a’R)-3’-(formyl)-7’-(methoxycarbonylmethyl)-5’-oxo-1-(phenylsulfonyl) spiro[indoline-3,1’-indolizidine]

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1’S,3’S,7’R,8a’R)-3’-(formyl)-7’-(methoxycarbonylmethyl)-5’-oxo-1-(phenylsulfonyl) spiro[indoline-3,1’-indolizidine]

Chemical Property:

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Technology Process of (1’S,3’S,7’R,8a’R)-3’-(formyl)-7’-(methoxycarbonylmethyl)-5’-oxo-1-(phenylsulfonyl) spiro[indoline-3,1’-indolizidine]

There total 5 articles about (1’S,3’S,7’R,8a’R)-3’-(formyl)-7’-(methoxycarbonylmethyl)-5’-oxo-1-(phenylsulfonyl) spiro[indoline-3,1’-indolizidine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1423035-81-7
(1’S,3’S,7’R,8a’R)-3’-(hydroxymethyl)-7’-(methoxycarbonylmethyl)-5’-oxo-1-(phenyl-sulfonyl)spiro[indoline-3,1’-indolizidine]

: 1423035-82-8
(1’S,3’S,7’R,8a’R)-3’-(formyl)-7’-(methoxycarbonylmethyl)-5’-oxo-1-(phenylsulfonyl) spiro[indoline-3,1’-indolizidine]

Guidance literature:: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 20 ℃; for 20h;
DOI:10.1039/c2cc38540f

Reference yield:

: 154-09-6,526-53-4,2899-29-8,52485-52-6
L-tryptophanol

: 1423035-82-8
(1’S,3’S,7’R,8a’R)-3’-(formyl)-7’-(methoxycarbonylmethyl)-5’-oxo-1-(phenylsulfonyl) spiro[indoline-3,1’-indolizidine]

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 24 h / Dean-Stark; Reflux

2: sodium hydroxide; tetrabutyl-ammonium chloride / water; dichloromethane / 0 - 20 °C

3: triethylsilane; titanium tetrachloride / dichloromethane / Inert atmosphere; Reflux

4: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 h / 20 °C

With triethylsilane; tetrabutyl-ammonium chloride; titanium tetrachloride; sodium hydroxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dichloromethane; water; dimethyl sulfoxide; toluene;
DOI:10.1039/c2cc38540f

Reference yield:

: 430461-02-2
dimethyl 3-(2-oxoethyl)pentan-1,5-dioate

: 1423035-82-8
(1’S,3’S,7’R,8a’R)-3’-(formyl)-7’-(methoxycarbonylmethyl)-5’-oxo-1-(phenylsulfonyl) spiro[indoline-3,1’-indolizidine]

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 24 h / Dean-Stark; Reflux

2: sodium hydroxide; tetrabutyl-ammonium chloride / water; dichloromethane / 0 - 20 °C

3: triethylsilane; titanium tetrachloride / dichloromethane / Inert atmosphere; Reflux

4: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 h / 20 °C

With triethylsilane; tetrabutyl-ammonium chloride; titanium tetrachloride; sodium hydroxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dichloromethane; water; dimethyl sulfoxide; toluene;
DOI:10.1039/c2cc38540f