C₂₃H₂₈FNO₂

Base Information

• Chemical Name: C₂₃H₂₈FNO₂
• CAS No.: 745075-94-9
• Molecular Formula: C₂₃H₂₈FNO₂
• Molecular Weight: 369.479
• Mol file: 745075-94-9.mol

Synonyms:C₂₃H₂₈FNO₂

Chemical Property of C₂₃H₂₈FNO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₈FNO₂

There total 4 articles about C₂₃H₂₈FNO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,2S)-1,2-diisopropyl-1,2-ethanediol (109785-53-7) → C23H28FNO2 (745075-94-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / para-toluenesulfonic acid monohydrate / benzene / 16 h / Heating

2: 81 percent / tri-tert-butylphosphine; cesium carbonate / tris(dibenzylideneacetone)dipalladium / tetrahydrofuran / 16 h / Heating

With tri-tert-butyl phosphine; caesium carbonate; toluene-4-sulfonic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; benzene; 2: Suzuki coupling;

DOI:10.1021/jo0494275

Reference yield:

2-chloro-6,7-dihydro-4-methyl-5H-cyclopenta[b]pyridin-7-yl acetate (267243-01-6) → C23H28FNO2 (745075-94-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 94 percent / lithium hydroxide monohydrate / tetrahydrofuran; H₂O / 16 h / 20 °C

2: 90 percent / oxalyl chloride; dimethyl sulfoxide; triethylamine / CH₂Cl₂ / -78 - 20 °C

3: 89 percent / para-toluenesulfonic acid monohydrate / benzene / 16 h / Heating

4: 81 percent / tri-tert-butylphosphine; cesium carbonate / tris(dibenzylideneacetone)dipalladium / tetrahydrofuran / 16 h / Heating

With lithium hydroxide; oxalyl dichloride; tri-tert-butyl phosphine; caesium carbonate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; benzene; 2: Swern oxidation / 4: Suzuki coupling;

DOI:10.1021/jo0494275

Reference yield:

2-chloro-6,7-dihydro-4-methyl-5H-cyclopenta[b]pyridin-7-ol (745075-80-3) → C23H28FNO2 (745075-94-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / oxalyl chloride; dimethyl sulfoxide; triethylamine / CH₂Cl₂ / -78 - 20 °C

2: 89 percent / para-toluenesulfonic acid monohydrate / benzene / 16 h / Heating

3: 81 percent / tri-tert-butylphosphine; cesium carbonate / tris(dibenzylideneacetone)dipalladium / tetrahydrofuran / 16 h / Heating

With oxalyl dichloride; tri-tert-butyl phosphine; caesium carbonate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; benzene; 1: Swern oxidation / 3: Suzuki coupling;

DOI:10.1021/jo0494275

upstream raw materials:

(1S,2S)-1,2-diisopropyl-1,2-ethanediol

2-chloro-6,7-dihydro-4-methyl-5H-cyclopenta[b]pyridin-7-yl acetate

2-chloro-5,6-dihydro-4-methyl-cyclopenta[b]pyridin-7-one

2-chloro-6,7-dihydro-4-methyl-5H-cyclopenta[b]pyridin-7-ol