(E)-2-((5-chloro-2-((5-ethylidene-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

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Chemical Name:(E)-2-((5-chloro-2-((5-ethylidene-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide
CAS No.:1564256-29-6
Molecular Formula:C₂₅H₂₇ClN₆O
Molecular Weight:462.982
Hs Code.:

Synonyms:(E)-2-((5-chloro-2-((5-ethylidene-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

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Chemical Property of (E)-2-((5-chloro-2-((5-ethylidene-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

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Technology Process of (E)-2-((5-chloro-2-((5-ethylidene-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

There total 7 articles about (E)-2-((5-chloro-2-((5-ethylidene-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.9%

: 761440-08-8
2-[(2,5-dichloropyrimidin-4-yl)amino]-N-methyl-benzamide

: 1564256-75-2
C₁₃H₁₈N₂

: 1564256-29-6
(E)-2-((5-chloro-2-((5-ethylidene-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: With (1S)-10-camphorsulfonic acid; In isopropyl alcohol; at 80 ℃; for 1h; Microwave irradiation;
DOI:10.1021/ml400373j

Reference yield:

: 1564256-61-6
C₁₉H₂₀N₂O₂

: 1564256-29-6
(E)-2-((5-chloro-2-((5-ethylidene-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / 1,2-dichloro-ethane / 2 h / Reflux

2.1: methanol / Reflux

3.1: acetic acid / dichloromethane / 0.5 h

3.2: 1 h / 20 °C

4.1: iron; ammonium chloride / ethanol; water / 1 h / Reflux

5.1: (1S)-10-camphorsulfonic acid / isopropyl alcohol / 1 h / 80 °C / Microwave irradiation

With (1S)-10-camphorsulfonic acid; iron; potassium carbonate; ammonium chloride; acetic acid; In methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; isopropyl alcohol;
DOI:10.1021/ml400373j

Reference yield:

: 1564256-64-9
C₁₂H₁₄N₂O₂

: 1564256-29-6
(E)-2-((5-chloro-2-((5-ethylidene-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / dichloromethane / 0.5 h

1.2: 1 h / 20 °C

2.1: iron; ammonium chloride / ethanol; water / 1 h / Reflux

3.1: (1S)-10-camphorsulfonic acid / isopropyl alcohol / 1 h / 80 °C / Microwave irradiation

With (1S)-10-camphorsulfonic acid; iron; ammonium chloride; acetic acid; In ethanol; dichloromethane; water; isopropyl alcohol;
DOI:10.1021/ml400373j