Technology Process of (3E,6R,9E,11R,14R)-11-Hydroxy-6,14-dimethyl-1,7-dioxacyclotetradeca-3,9-diene-2,8-dione
There total 40 articles about (3E,6R,9E,11R,14R)-11-Hydroxy-6,14-dimethyl-1,7-dioxacyclotetradeca-3,9-diene-2,8-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
chloro-trimethyl-silane; tetrabutylammomium bromide;
In
dichloromethane;
at -10 - 0 ℃;
for 2h;
DOI:10.1055/s-0029-1218270
- Guidance literature:
-
Multi-step reaction with 9 steps
1: lead tetraacetate / benzene / Ambient temperature
2: 90 percent / diethyl phosphorochloridate, triethylamine, 4-(dimethylamino)pyridine / benzene / Ambient temperature
3: sodium borohydride / tetrahydrofuran
4: H2 / 5percent Pd-C / ethyl acetate
5: 1) diethyl phosphorochloridate, triethylamine 2) 4-(dimethylamino)pyridine / 1) acetonitrile, -15 deg C, 2 h; 2) acetonitrile, reflux, 12 h
6: LDA / tetrahydrofuran / -78 °C
7: H2O2 / H2O; acetic acid / 0 °C
8: trifluoroacetic acid / CH2Cl2 / Ambient temperature
9: sodium borohydride, cerium chloride / methanol
With
lead(IV) acetate; dmap; sodium tetrahydroborate; cerium(III) chloride; hydrogen; dihydrogen peroxide; diethyl chlorophosphate; triethylamine; trifluoroacetic acid; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water; acetic acid; ethyl acetate; benzene;
DOI:10.1016/S0040-4039(00)98360-6
