(4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-((2-(non-2-yn-1-ylsulfonyl)ethyl)amino)-3-oxopropyl)-1,3-dioxane-4-carboxamide

Base Information

Chemical Name:(4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-((2-(non-2-yn-1-ylsulfonyl)ethyl)amino)-3-oxopropyl)-1,3-dioxane-4-carboxamide
CAS No.:1441770-02-0
Molecular Formula:C₂₈H₄₂N₂O₇S
Molecular Weight:550.717
Hs Code.:

Synonyms:(4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-((2-(non-2-yn-1-ylsulfonyl)ethyl)amino)-3-oxopropyl)-1,3-dioxane-4-carboxamide

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Chemical Property of (4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-((2-(non-2-yn-1-ylsulfonyl)ethyl)amino)-3-oxopropyl)-1,3-dioxane-4-carboxamide

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Technology Process of (4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-((2-(non-2-yn-1-ylsulfonyl)ethyl)amino)-3-oxopropyl)-1,3-dioxane-4-carboxamide

There total 5 articles about (4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-((2-(non-2-yn-1-ylsulfonyl)ethyl)amino)-3-oxopropyl)-1,3-dioxane-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1441769-94-3
(4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-((2-(non-2-yn-1-ylthio)ethyl)amino)-3-oxopropyl)-1,3-dioxane-4-carboxamide

: 1441770-02-0
(4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-((2-(non-2-yn-1-ylsulfonyl)ethyl)amino)-3-oxopropyl)-1,3-dioxane-4-carboxamide

Guidance literature:: With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; at 20 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1021/ja4042059

Reference yield:

: 1353894-47-9
tert-butyl (2-(non-2-yn-1-ylthio)ethyl)carbamate

: 1441770-02-0
(4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-((2-(non-2-yn-1-ylsulfonyl)ethyl)amino)-3-oxopropyl)-1,3-dioxane-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 2 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 20 °C / Inert atmosphere

3: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / diethyl ether / 0.33 h / 20 °C / Inert atmosphere

With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In diethyl ether; dichloromethane;
DOI:10.1021/ja4042059

Reference yield:

: 5921-73-3
2-nonyn-1-ol

: 1441770-02-0
(4R)-2-(4-methoxyphenyl)-5,5-dimethyl-N-(3-((2-(non-2-yn-1-ylsulfonyl)ethyl)amino)-3-oxopropyl)-1,3-dioxane-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

3: dichloromethane / 2 h / 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 20 °C / Inert atmosphere

5: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / diethyl ether / 0.33 h / 20 °C / Inert atmosphere

With N-chloro-succinimide; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja4042059