N-methyl-N-methoxy-2-tert-butyldimethylsilyloxy-2-(4-fluorophenyl)acetamide

Base Information

Chemical Name:N-methyl-N-methoxy-2-tert-butyldimethylsilyloxy-2-(4-fluorophenyl)acetamide
CAS No.:660432-04-2
Molecular Formula:C₁₆H₂₆FNO₃Si
Molecular Weight:327.471
Hs Code.:

Synonyms:N-methyl-N-methoxy-2-tert-butyldimethylsilyloxy-2-(4-fluorophenyl)acetamide

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Chemical Property of N-methyl-N-methoxy-2-tert-butyldimethylsilyloxy-2-(4-fluorophenyl)acetamide

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Technology Process of N-methyl-N-methoxy-2-tert-butyldimethylsilyloxy-2-(4-fluorophenyl)acetamide

There total 1 articles about N-methyl-N-methoxy-2-tert-butyldimethylsilyloxy-2-(4-fluorophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 660432-05-3
N-[methyl] N-[methoxy] 2-hydroxy-2-(4-fluorophenyl)acetamide

: 69739-34-0
t-butyldimethylsiyl triflate

: 660432-04-2
N-methyl-N-methoxy-2-tert-butyldimethylsilyloxy-2-(4-fluorophenyl)acetamide

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 5h;

Reference yield: 66.0%

: 660432-04-2
N-methyl-N-methoxy-2-tert-butyldimethylsilyloxy-2-(4-fluorophenyl)acetamide

: 208335-92-6
6-iodo-1-(propane-2-sulfonyl)-1H-benzimidazole-2-ylamine

: 660432-08-6
1-[2-amino-3-(propane-2-sulfonyl)-3H-benzimidazol-5-yl]-2-(tert-butyldimethylsilanyloxy)-2-(4-fluorophenyl)ethanone

Guidance literature:: 6-iodo-1-(propane-2-sulfonyl)-1H-benzimidazole-2-ylamine; With isopropylmagnesium chloride; In tetrahydrofuran; at -60 - -5 ℃;

N-methyl-N-methoxy-2-tert-butyldimethylsilyloxy-2-(4-fluorophenyl)acetamide; In tetrahydrofuran; at 0 - 15 ℃;
DOI:10.1021/jm048978k

Reference yield:

: 660432-04-2
N-methyl-N-methoxy-2-tert-butyldimethylsilyloxy-2-(4-fluorophenyl)acetamide

: 6-[5-(4-fluorophenyl)-3H-imidazol-4-yl]-1-(propane-2-sulfonyl)-1H-benzimidazole-2-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: iPrMgCl / tetrahydrofuran / -60 - -5 °C

1.2: 66 percent / tetrahydrofuran / 0 - 15 °C

2.1: 22 percent / Cu(OAc)2; NH₄OAc; acetic acid / 80 - 90 °C

With copper diacetate; ammonium acetate; isopropylmagnesium chloride; acetic acid; In tetrahydrofuran;
DOI:10.1021/jm048978k