3-[acetyl-2-(benzylidene)hydrazino]-4-[2-(acetoxy)-1-nitropropen-1-yl]phenyl acetate

Base Information

• Chemical Name: 3-[acetyl-2-(benzylidene)hydrazino]-4-[2-(acetoxy)-1-nitropropen-1-yl]phenyl acetate
• CAS No.: 773885-81-7
• Molecular Formula: C₂₂H₂₁N₃O₇
• Molecular Weight: 439.425
• Mol file: 773885-81-7.mol

Synonyms:3-[acetyl-2-(benzylidene)hydrazino]-4-[2-(acetoxy)-1-nitropropen-1-yl]phenyl acetate

Chemical Property of 3-[acetyl-2-(benzylidene)hydrazino]-4-[2-(acetoxy)-1-nitropropen-1-yl]phenyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[acetyl-2-(benzylidene)hydrazino]-4-[2-(acetoxy)-1-nitropropen-1-yl]phenyl acetate

There total 2 articles about 3-[acetyl-2-(benzylidene)hydrazino]-4-[2-(acetoxy)-1-nitropropen-1-yl]phenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

acetic anhydride (108-24-7) + 1-benzylideneamino-6-hydroxy-2-methyl-3-nitro-1H-indole (773885-79-3) → 1-acetylamino-2-methyl-3-nitro-6-acetoxyindole (773885-82-8) + 3-[acetyl-2-(benzylidene)hydrazino]-4-[2-(acetoxy)-1-nitropropen-1-yl]phenyl acetate (773885-81-7)

Guidance literature:

With sulfuric acid; at 20 ℃; for 1.5h;

DOI:10.1007/s11172-005-0198-3

Reference yield:

N-benzylidene-N'-(1-methyl-2-nitrovinyl)hydrazine → 3-[acetyl-2-(benzylidene)hydrazino]-4-[2-(acetoxy)-1-nitropropen-1-yl]phenyl acetate (773885-81-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 24 percent / toluenesulfonic acid / acetic acid / 3 h / 20 °C

2: 63 percent / H₂SO₄ / 1.5 h / 20 °C

With sulfuric acid; o-toluenesulfonic acid; In acetic acid; 1: Nenitzescu reaction;

DOI:10.1007/s11172-005-0198-3

Reference yield: 92.0%

3-[acetyl-2-(benzylidene)hydrazino]-4-[2-(acetoxy)-1-nitropropen-1-yl]phenyl acetate (773885-81-7) → 1-acetylamino-2-methyl-3-nitro-6-hydroxyindole (773885-83-9) + 1-benzylideneamino-6-hydroxy-2-methyl-3-nitro-1H-indole (773885-79-3)

Guidance literature:

With hydrogenchloride; water; In ethanol; for 0.333333h; Heating;

DOI:10.1070/MC2004v014n02ABEH001879

upstream raw materials:

acetic anhydride

1-benzylideneamino-6-hydroxy-2-methyl-3-nitro-1H-indole

Downstream raw materials:

1-acetylamino-2-methyl-3-nitro-6-hydroxyindole

1-benzylideneamino-6-hydroxy-2-methyl-3-nitro-1H-indole