carbonic acid allyl ester 4-[(S)-2-[allyloxycarbonyl-(3,5-bis-allyloxy-4-bromo-benzyl)-amino]-3-(triisopropyl-silanyloxy)-propyl]-phenyl ester

Base Information

• Chemical Name: carbonic acid allyl ester 4-[(S)-2-[allyloxycarbonyl-(3,5-bis-allyloxy-4-bromo-benzyl)-amino]-3-(triisopropyl-silanyloxy)-propyl]-phenyl ester
• CAS No.: 355121-65-2
• Molecular Formula: C₃₉H₅₄BrNO₈Si
• Molecular Weight: 772.849
• Mol file: 355121-65-2.mol

Synonyms:carbonic acid allyl ester 4-[(S)-2-[allyloxycarbonyl-(3,5-bis-allyloxy-4-bromo-benzyl)-amino]-3-(triisopropyl-silanyloxy)-propyl]-phenyl ester

Chemical Property of carbonic acid allyl ester 4-[(S)-2-[allyloxycarbonyl-(3,5-bis-allyloxy-4-bromo-benzyl)-amino]-3-(triisopropyl-silanyloxy)-propyl]-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of carbonic acid allyl ester 4-[(S)-2-[allyloxycarbonyl-(3,5-bis-allyloxy-4-bromo-benzyl)-amino]-3-(triisopropyl-silanyloxy)-propyl]-phenyl ester

There total 12 articles about carbonic acid allyl ester 4-[(S)-2-[allyloxycarbonyl-(3,5-bis-allyloxy-4-bromo-benzyl)-amino]-3-(triisopropyl-silanyloxy)-propyl]-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4[(S)-2-(3,5-bis-allyloxy-4-bromo-benzylamino)-3-(triisopropyl-silanyloxy)-propyl]-phenol (355121-64-1) + Allyl chloroformate (2937-50-0) → carbonic acid allyl ester 4-[(S)-2-[allyloxycarbonyl-(3,5-bis-allyloxy-4-bromo-benzyl)-amino]-3-(triisopropyl-silanyloxy)-propyl]-phenyl ester (355121-65-2)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 1.5h;

DOI:10.1021/ja016093h

Reference yield: 97.0%

4[(S)-2-(3,5-bis-allyloxy-4-bromo-benzylamino)-3-(triisopropyl-silanyloxy)-propyl]-phenol (355121-64-1) + 2,6-dimethylpyridine (108-48-5) + aqueous ammonium chloride + Allyl chloroformate (2937-50-0) → carbonic acid allyl ester 4-[(S)-2-[allyloxycarbonyl-(3,5-bis-allyloxy-4-bromo-benzyl)-amino]-3-(triisopropyl-silanyloxy)-propyl]-phenyl ester (355121-65-2)

Guidance literature:

In dichloromethane;

Reference yield:

(S)-2-allyloxycarbonylamino-3-(4-hydroxy-phenyl)-propionic acid methyl ester (355121-59-4) → carbonic acid allyl ester 4-[(S)-2-[allyloxycarbonyl-(3,5-bis-allyloxy-4-bromo-benzyl)-amino]-3-(triisopropyl-silanyloxy)-propyl]-phenyl ester (355121-65-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 92 percent / K₂CO₃ / dimethylformamide / 9 h / 20 °C

2: 80 percent / lithium chloride; sodium borohydride; ethanol / tetrahydrofuran / 19 h / 20 °C

3: 88 percent / diisopropylethylamine / CH₂Cl₂ / 0 - 20 °C

4: morpholine / tetrahydrofuran / 10 h / 47 °C

5: 66 percent / acetic acid; sodium cyanoborohydride / methanol / 15 h / 20 °C

6: 97 percent / 2,6-lutidine / CH₂Cl₂ / 1.5 h / 20 °C

With morpholine; 2,6-dimethylpyridine; sodium tetrahydroborate; ethanol; sodium cyanoborohydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja016093h

upstream raw materials:

4[(S)-2-(3,5-bis-allyloxy-4-bromo-benzylamino)-3-(triisopropyl-silanyloxy)-propyl]-phenol

Allyl chloroformate

(S)-2-allyloxycarbonylamino-3-(4-hydroxy-phenyl)-propionic acid methyl ester

3,5-bis-allyloxy-4-bromo-benzaldehyde