methyl 4-[4-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]benzoate

Base Information

Chemical Name:methyl 4-[4-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]benzoate
CAS No.:863767-91-3
Molecular Formula:C₁₈H₂₀N₄O₃
Molecular Weight:340.382
Hs Code.:

Synonyms:methyl 4-[4-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]benzoate

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Chemical Property of methyl 4-[4-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]benzoate

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Technology Process of methyl 4-[4-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]benzoate

There total 5 articles about methyl 4-[4-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1051473-24-5
methyl 4-(6-bromo-5-oxohexyl)benzoate

: 56-06-4
2,6-diaminopyrimidin-4-ol

: 863767-91-3
methyl 4-[4-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]benzoate

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 72h; Inert atmosphere;
DOI:10.1021/jm8003366

Reference yield:

: 863767-86-6
(4E/Z)-5-[4-(methoxycarbonyl)phenyl]pent-4-enoic acid

: 863767-91-3
methyl 4-[4-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 98 percent / H₂ / Pd/C / CHCl₃; ethyl acetate / 2327.17 - 2585.74 Torr

2.1: oxalyl chloride / CH₂Cl₂ / 1 h / Heating

3.1: diethyl ether

3.2: 2 g / aq. HCl / diethyl ether / 1.5 h / Heating

4.1: 38 percent / dimethylformamide / 72 h / 40 - 50 °C

With oxalyl dichloride; hydrogen; palladium on activated charcoal; In diethyl ether; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm058213s

Reference yield:

: 17857-14-6
(3-carboxypropyl)(triphenyl)phosphonium bromide

: 863767-91-3
methyl 4-[4-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 94 percent / NaH / dimethylsulfoxide; tetrahydrofuran / 6.5 h / 0 - 20 °C

2.1: 98 percent / H₂ / Pd/C / CHCl₃; ethyl acetate / 2327.17 - 2585.74 Torr

3.1: oxalyl chloride / CH₂Cl₂ / 1 h / Heating

4.1: diethyl ether

4.2: 2 g / aq. HCl / diethyl ether / 1.5 h / Heating

5.1: 38 percent / dimethylformamide / 72 h / 40 - 50 °C

With oxalyl dichloride; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; 1.1: Wittig reaction;
DOI:10.1021/jm058213s