Technology Process of methyl 4-[4-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]benzoate
There total 5 articles about methyl 4-[4-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
N,N-dimethyl-formamide;
at 20 ℃;
for 72h;
Inert atmosphere;
DOI:10.1021/jm8003366
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 98 percent / H2 / Pd/C / CHCl3; ethyl acetate / 2327.17 - 2585.74 Torr
2.1: oxalyl chloride / CH2Cl2 / 1 h / Heating
3.1: diethyl ether
3.2: 2 g / aq. HCl / diethyl ether / 1.5 h / Heating
4.1: 38 percent / dimethylformamide / 72 h / 40 - 50 °C
With
oxalyl dichloride; hydrogen;
palladium on activated charcoal;
In
diethyl ether; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm058213s
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 94 percent / NaH / dimethylsulfoxide; tetrahydrofuran / 6.5 h / 0 - 20 °C
2.1: 98 percent / H2 / Pd/C / CHCl3; ethyl acetate / 2327.17 - 2585.74 Torr
3.1: oxalyl chloride / CH2Cl2 / 1 h / Heating
4.1: diethyl ether
4.2: 2 g / aq. HCl / diethyl ether / 1.5 h / Heating
5.1: 38 percent / dimethylformamide / 72 h / 40 - 50 °C
With
oxalyl dichloride; hydrogen; sodium hydride;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; dichloromethane; chloroform; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;
1.1: Wittig reaction;
DOI:10.1021/jm058213s
