dimethylcarbamic acid 4-[3-(tert-butyldiphenylsilanyloxy)-1-hydroxypropyl]-3-vinylphenyl ester

Base Information

Chemical Name:dimethylcarbamic acid 4-[3-(tert-butyldiphenylsilanyloxy)-1-hydroxypropyl]-3-vinylphenyl ester
CAS No.:444646-69-9
Molecular Formula:C₃₀H₃₇NO₄Si
Molecular Weight:503.714
Hs Code.:

Synonyms:dimethylcarbamic acid 4-[3-(tert-butyldiphenylsilanyloxy)-1-hydroxypropyl]-3-vinylphenyl ester

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Chemical Property of dimethylcarbamic acid 4-[3-(tert-butyldiphenylsilanyloxy)-1-hydroxypropyl]-3-vinylphenyl ester

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Technology Process of dimethylcarbamic acid 4-[3-(tert-butyldiphenylsilanyloxy)-1-hydroxypropyl]-3-vinylphenyl ester

There total 5 articles about dimethylcarbamic acid 4-[3-(tert-butyldiphenylsilanyloxy)-1-hydroxypropyl]-3-vinylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 444646-68-8
4-(1,3-dihydroxy-propyl)-3-vinyl-phenyl dimethylcarbamate

: 444646-69-9
dimethylcarbamic acid 4-[3-(tert-butyldiphenylsilanyloxy)-1-hydroxypropyl]-3-vinylphenyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 95-01-2
2,4-Dihydroxybenzaldehyde

: 444646-69-9
dimethylcarbamic acid 4-[3-(tert-butyldiphenylsilanyloxy)-1-hydroxypropyl]-3-vinylphenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 30 percent / NaH / dimethylformamide / 2 h / 20 °C

2.1: 4.14 g / pyridine / CH₂Cl₂ / 1 h / 0 °C

3.1: 2.11 g / Pd(PPh₃)4; LiCl; 2,6-di-t-butylphenol / dioxane / 3 h / 100 °C

4.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.33 h / -78 °C

4.2: 99 percent / tetrahydrofuran; hexane / 0.5 h / -78 °C

5.1: 97 percent / LiBH₄ / tetrahydrofuran / 1 h / 20 °C

6.1: 70 percent / 4-dimethylaminopyridine; triethylamine / CH₂Cl₂ / 5 h / 20 °C

With pyridine; dmap; lithium borohydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butylphenol; sodium hydride; triethylamine; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; 3.1: Stille reaction;
DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 444646-66-6
dimethylcarbamic acid 4-formyl-3-vinylphenyl ester

: 444646-69-9
dimethylcarbamic acid 4-[3-(tert-butyldiphenylsilanyloxy)-1-hydroxypropyl]-3-vinylphenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.33 h / -78 °C

1.2: 99 percent / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.1: 97 percent / LiBH₄ / tetrahydrofuran / 1 h / 20 °C

3.1: 70 percent / 4-dimethylaminopyridine; triethylamine / CH₂Cl₂ / 5 h / 20 °C

With dmap; lithium borohydride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/S0968-0896(03)00452-8