ethyl (1S,2R,3S,5R)-2-benzamido-3,5-di(3’-methoxy-3’-oxopropyl)cyclopentanecarboxylate

Base Information

Chemical Name:ethyl (1S,2R,3S,5R)-2-benzamido-3,5-di(3’-methoxy-3’-oxopropyl)cyclopentanecarboxylate
CAS No.:1446558-43-5
Molecular Formula:C₂₃H₃₁NO₇
Molecular Weight:433.502
Hs Code.:

Synonyms:ethyl (1S,2R,3S,5R)-2-benzamido-3,5-di(3’-methoxy-3’-oxopropyl)cyclopentanecarboxylate

Suppliers and Price of ethyl (1S,2R,3S,5R)-2-benzamido-3,5-di(3’-methoxy-3’-oxopropyl)cyclopentanecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (1S,2R,3S,5R)-2-benzamido-3,5-di(3’-methoxy-3’-oxopropyl)cyclopentanecarboxylate

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Technology Process of ethyl (1S,2R,3S,5R)-2-benzamido-3,5-di(3’-methoxy-3’-oxopropyl)cyclopentanecarboxylate

There total 8 articles about ethyl (1S,2R,3S,5R)-2-benzamido-3,5-di(3’-methoxy-3’-oxopropyl)cyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: ethyl (1S,2R,3R,5S)-2-benzamido-3,5-di(3’-methoxy-3’-oxoprop-1-enyl)cyclopentanecarboxylate

: 1446558-43-5
ethyl (1S,2R,3S,5R)-2-benzamido-3,5-di(3’-methoxy-3’-oxopropyl)cyclopentanecarboxylate

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 1h; enantioselective reaction;
DOI:10.1002/chem.201203183

Reference yield:

: 14735-70-7,14805-31-3,924272-78-6,670221-11-1
diexo-3-Aza-4-oxotricyclo<4.2.1.0^2,5>non-7-ene

: 1446558-43-5
ethyl (1S,2R,3S,5R)-2-benzamido-3,5-di(3’-methoxy-3’-oxopropyl)cyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: water / 168 h / 70 °C / Enzymatic reaction

2: hydrogenchloride / 0 °C

3: sodium hydrogencarbonate / toluene / 0 °C

4: 4-methylmorpholine N-oxide; osmium(VIII) oxide / acetone / 12 h / 20 °C

5: sodium periodate / water; tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

6: tetrahydrofuran / 1.16 h / 0 - 20 °C

7: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 1 h / 20 °C

With hydrogenchloride; sodium periodate; osmium(VIII) oxide; 5%-palladium/activated carbon; water; hydrogen; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; ethyl acetate; acetone; toluene; 6: |Wittig Rearrangement;
DOI:10.1002/chem.201203183

Reference yield:

: 924272-78-6,670221-11-1
(1R,2R,5S,6S)-3-azatricyclo[4.2.1.0^2,5]non-7-en-4-one

: 1446558-43-5
ethyl (1S,2R,3S,5R)-2-benzamido-3,5-di(3’-methoxy-3’-oxopropyl)cyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / 0 °C

2: sodium hydrogencarbonate / toluene / 0 °C

3: 4-methylmorpholine N-oxide; osmium(VIII) oxide / acetone / 12 h / 20 °C

4: sodium periodate / water; tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

5: tetrahydrofuran / 1.16 h / 0 - 20 °C

6: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 1 h / 20 °C

With hydrogenchloride; sodium periodate; osmium(VIII) oxide; 5%-palladium/activated carbon; hydrogen; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; ethyl acetate; acetone; toluene; 5: |Wittig Rearrangement;
DOI:10.1002/chem.201203183