methyl 4-<2-<1-(4-chlorophenyl)-2-oxo-pyrrolidin-4-yl>ethyloxy>benzoate

Base Information

Chemical Name:methyl 4-<2-<1-(4-chlorophenyl)-2-oxo-pyrrolidin-4-yl>ethyloxy>benzoate
CAS No.:133748-69-3
Molecular Formula:C₂₀H₂₀ClNO₄
Molecular Weight:373.836
Hs Code.:

Synonyms:methyl 4-<2-<1-(4-chlorophenyl)-2-oxo-pyrrolidin-4-yl>ethyloxy>benzoate

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Chemical Property of methyl 4-<2-<1-(4-chlorophenyl)-2-oxo-pyrrolidin-4-yl>ethyloxy>benzoate

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Technology Process of methyl 4-<2-<1-(4-chlorophenyl)-2-oxo-pyrrolidin-4-yl>ethyloxy>benzoate

There total 11 articles about methyl 4-<2-<1-(4-chlorophenyl)-2-oxo-pyrrolidin-4-yl>ethyloxy>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 1027083-49-3
Methanesulfonic acid 2-[1-(4-chloro-phenyl)-5-oxo-pyrrolidin-3-yl]-ethyl ester

: 133748-69-3
methyl 4-<2-<1-(4-chlorophenyl)-2-oxo-pyrrolidin-4-yl>ethyloxy>benzoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; Yield given;
DOI:10.1016/0223-5234(94)90029-9

Reference yield:

: 133748-68-2
1-(4-Chlorophenyl)-4-(2-hydroxyethyl}-2-pyrrolidone

: 133748-69-3
methyl 4-<2-<1-(4-chlorophenyl)-2-oxo-pyrrolidin-4-yl>ethyloxy>benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂

2: K₂CO₃ / dimethylformamide / 80 °C

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(94)90029-9

Reference yield:

: 97-65-4,25119-64-6
2-methylenesuccinic acid

: 133748-69-3
methyl 4-<2-<1-(4-chlorophenyl)-2-oxo-pyrrolidin-4-yl>ethyloxy>benzoate

Guidance literature:: Multi-step reaction with 10 steps

1: 93.5 percent / Heating

2: 92.6 percent / conc. H₂SO₄ / CH₂Cl₂ / Heating

3: 99 percent / NaBH₄, MeOH / tetrahydrofuran / Heating

4: Et₃N / CH₂Cl₂

5: 84.1 percent / dimethylformamide / 22 h / 100 °C

6: NaOH, H₂O / ethanol / 8 h / Heating

7: conc. H₂SO₄ / 15 h / Heating

8: 90.2 percent / NaBH₄, MeOH / tetrahydrofuran / Heating

9: Et₃N / CH₂Cl₂

10: K₂CO₃ / dimethylformamide / 80 °C

With methanol; sodium hydroxide; sodium tetrahydroborate; sulfuric acid; water; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(94)90029-9