Technology Process of (2E,6E)-2-(3,4-dihydroxybenzylidene)-3-oxo-7-phenylhept-6-enenitrile
There total 4 articles about (2E,6E)-2-(3,4-dihydroxybenzylidene)-3-oxo-7-phenylhept-6-enenitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: carbon tetrabromide; triphenylphosphine / acetonitrile / 13 h / 0 °C / Inert atmosphere; Darkness
2.1: copper(l) iodide; lithium diisopropyl amide / tetrahydrofuran; hexane / 2 h / -30 °C / Inert atmosphere
2.2: 1.5 h / -30 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 °C / Inert atmosphere
3.2: -78 - 20 °C
4.1: piperidine / dichloromethane / 20 °C / Inert atmosphere
With
piperidine; copper(l) iodide; n-butyllithium; carbon tetrabromide; triphenylphosphine; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; dichloromethane; acetonitrile;
4.1: |Knoevenagel Condensation;
DOI:10.1016/j.ejmech.2014.01.049
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: copper(l) iodide; lithium diisopropyl amide / tetrahydrofuran; hexane / 2 h / -30 °C / Inert atmosphere
1.2: 1.5 h / -30 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C
3.1: piperidine / dichloromethane / 20 °C / Inert atmosphere
With
piperidine; copper(l) iodide; n-butyllithium; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; dichloromethane;
3.1: |Knoevenagel Condensation;
DOI:10.1016/j.ejmech.2014.01.049