tert-butyl N₂-[(benzyloxy)carbonyl]-N₅-(N,N'-bis[(benzyloxy)carbonyl]carbamimidoyl)-L-ornithyl-N₅-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-D-glutaminate

Base Information

• Chemical Name: tert-butyl N₂-[(benzyloxy)carbonyl]-N₅-(N,N'-bis[(benzyloxy)carbonyl]carbamimidoyl)-L-ornithyl-N₅-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-D-glutaminate
• CAS No.: 1375014-35-9
• Molecular Formula: C₅₈H₇₄N₈O₁₁
• Molecular Weight: 1059.27

Synonyms:tert-butyl N₂-[(benzyloxy)carbonyl]-N₅-(N,N'-bis[(benzyloxy)carbonyl]carbamimidoyl)-L-ornithyl-N₅-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-D-glutaminate

Chemical Property of tert-butyl N₂-[(benzyloxy)carbonyl]-N₅-(N,N'-bis[(benzyloxy)carbonyl]carbamimidoyl)-L-ornithyl-N₅-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-D-glutaminate

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Technology Process of tert-butyl N₂-[(benzyloxy)carbonyl]-N₅-(N,N'-bis[(benzyloxy)carbonyl]carbamimidoyl)-L-ornithyl-N₅-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-D-glutaminate

There total 2 articles about tert-butyl N₂-[(benzyloxy)carbonyl]-N₅-(N,N'-bis[(benzyloxy)carbonyl]carbamimidoyl)-L-ornithyl-N₅-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-D-glutaminate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

tert-butyl N5-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-D-glutaminate (1375014-16-6) + Nα,Nω,Nω'-Tris(benzyloxycarbonyl)-L-arginin (1947-42-8,20888-05-5) → tert-butyl N2-[(benzyloxy)carbonyl]-N5-(N,N'-bis[(benzyloxy)carbonyl]carbamimidoyl)-L-ornithyl-N5-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-D-glutaminate (1375014-35-9)

Guidance literature:

With diisopropyl-carbodiimide; In dichloromethane; at 20 ℃; Cooling with ice;

DOI:10.1016/j.ejmech.2012.03.019

Reference yield:

tert-butyl N5-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-N2-[(9H-fluoren-9-yl-methoxy)carbonyl]-D-glutaminate (1375014-08-6) → tert-butyl N2-[(benzyloxy)carbonyl]-N5-(N,N'-bis[(benzyloxy)carbonyl]carbamimidoyl)-L-ornithyl-N5-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-D-glutaminate (1375014-35-9)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / dichloromethane / 0.33 h / 20 °C

2: diisopropyl-carbodiimide / dichloromethane / 20 °C / Cooling with ice

With piperidine; diisopropyl-carbodiimide; In dichloromethane;

DOI:10.1016/j.ejmech.2012.03.019

upstream raw materials:

tert-butyl N₅-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-N₂-[(9H-fluoren-9-yl-methoxy)carbonyl]-D-glutaminate

tert-butyl N₅-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-D-glutaminate

N^α,N^ω,N^ω'-Tris(benzyloxycarbonyl)-L-arginin

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