3-butoxy-3-(2-fluorophenyl)azetidine trifluoroacetate

Base Information

• Chemical Name: 3-butoxy-3-(2-fluorophenyl)azetidine trifluoroacetate
• CAS No.: 1225439-49-5
• Molecular Formula: C₂HF₃O₂*C₁₃H₁₈FNO
• Molecular Weight: 337.314
• Mol file: 1225439-49-5.mol

Synonyms:3-butoxy-3-(2-fluorophenyl)azetidine trifluoroacetate

Chemical Property of 3-butoxy-3-(2-fluorophenyl)azetidine trifluoroacetate

Chemical Property:

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Technology Process of 3-butoxy-3-(2-fluorophenyl)azetidine trifluoroacetate

There total 1 articles about 3-butoxy-3-(2-fluorophenyl)azetidine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-butoxy-3-(2-fluorophenyl)-1-(tert-butoxycarbonyl)azetidine (1225439-47-3) + trifluoroacetic acid (76-05-1) → 3-butoxy-3-(2-fluorophenyl)azetidine trifluoroacetate (1225439-49-5)

Guidance literature:

In dichloromethane; at 0 ℃; for 0.5h;

Reference yield: 58.0%

3-butoxy-3-(2-fluorophenyl)azetidine trifluoroacetate (1225439-49-5) + N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine (68856-96-2) → tert-butyl [(R)-2-[3-butoxy-3-(2-fluorophenyl)-azetidin-1-yl]-1-(4-methoxybenzyl)-2-oxoethyl]carbamate (1225439-50-8)

Guidance literature:

3-butoxy-3-(2-fluorophenyl)azetidine trifluoroacetate; N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 0.0833333h; Inert atmosphere;

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 23h;

upstream raw materials:

3-butoxy-3-(2-fluorophenyl)-1-(tert-butoxycarbonyl)azetidine

trifluoroacetic acid

Downstream raw materials:

tert-butyl [(R)-2-[3-butoxy-3-(2-fluorophenyl)-azetidin-1-yl]-1-(4-methoxybenzyl)-2-oxoethyl]carbamate