{(S)-1-[(S)-2-(4-Fluoro-3-nitro-phenyl)-2-hydroxy-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{(S)-1-[(S)-2-(4-Fluoro-3-nitro-phenyl)-2-hydroxy-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester
CAS No.:856165-52-1
Molecular Formula:C₂₂H₂₆FN₃O₆
Molecular Weight:447.463
Hs Code.:

Synonyms:{(S)-1-[(S)-2-(4-Fluoro-3-nitro-phenyl)-2-hydroxy-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Suppliers and Price of {(S)-1-[(S)-2-(4-Fluoro-3-nitro-phenyl)-2-hydroxy-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {(S)-1-[(S)-2-(4-Fluoro-3-nitro-phenyl)-2-hydroxy-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {(S)-1-[(S)-2-(4-Fluoro-3-nitro-phenyl)-2-hydroxy-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

There total 1 articles about {(S)-1-[(S)-2-(4-Fluoro-3-nitro-phenyl)-2-hydroxy-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: (1S)-1-(4'-fluoro-3'-nitro)phenyl-2-amino-ethanol hydrochloride

: 856165-52-1
{(S)-1-[(S)-2-(4-Fluoro-3-nitro-phenyl)-2-hydroxy-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;
DOI:10.1002/chem.200401070

Reference yield:

: 856165-52-1
{(S)-1-[(S)-2-(4-Fluoro-3-nitro-phenyl)-2-hydroxy-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

: (3S,7S,10S,14S)-18-Amino-6,10-dibenzyl-14-hydroxy-2-oxa-6,9,12-triaza-tricyclo[13.2.2.0^3,7]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-triene-8,11-dione

Guidance literature:: Multi-step reaction with 4 steps

1: aq. HCl / acetonitrile / 1 h / 20 °C

2: 2.49 g / Et₃N; HOBT; EDCI / dimethylformamide / 17 h / 20 °C

3: 251 mg / TBAF; 3 Angstroem molecular sieves / dimethylsulfoxide; tetrahydrofuran / 20 h / 60 °C

4: H₂ / Pd/C / ethyl acetate; methanol / 2.5 h / 20 °C

With hydrogenchloride; 3 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chem.200401070

Reference yield:

: 856165-52-1
{(S)-1-[(S)-2-(4-Fluoro-3-nitro-phenyl)-2-hydroxy-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

: 856165-46-3
[(S)-1-((Z)-(3S,7S,10S)-10-Benzyl-8,11-dioxo-2-oxa-6,9,12-triaza-tricyclo[13.2.2.0^3,7]nonadeca-1⁽¹⁸⁾,13,15⁽¹⁹⁾,16-tetraene-6-carbonyl)-2-methyl-propyl]-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: aq. HCl / acetonitrile / 1 h / 20 °C

2.1: 2.49 g / Et₃N; HOBT; EDCI / dimethylformamide / 17 h / 20 °C

3.1: 251 mg / TBAF; 3 Angstroem molecular sieves / dimethylsulfoxide; tetrahydrofuran / 20 h / 60 °C

4.1: H₂ / Pd/C / ethyl acetate; methanol / 2.5 h / 20 °C

5.1: 32.6 mg / aq. H₃PO₂; NaNO₂; Cu₂O / SnCl₂ / tetrahydrofuran / 4 h / 0 - 20 °C

6.1: 82 percent / H₂ / Pd/C / methanol / 72 h / 20 °C

7.1: 87 percent / DIEA; HATU / dimethylformamide / 17 h / 20 °C

8.1: Et₃n / CH₂Cl₂ / 1 h / -15 °C

9.1: NaBH₄ / ethanol / 0 °C

9.2: 55 mg / ethanol / 2 h / 80 °C

10.1: pyridine; aq. H₂O₂ / CH₂Cl₂ / 1.33 h / 0 - 20 °C

11.1: 8.5 mg / benzene / 2 h / 60 °C

With pyridine; copper(I) oxide; hydrogenchloride; sodium tetrahydroborate; 3 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; dihydrogen peroxide; hypophosphorous acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium nitrite; palladium on activated charcoal; tin(ll) chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1002/chem.200401070