bis(2-cyanoethyl)-2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl-1-phosphate

Base Information

Chemical Name:bis(2-cyanoethyl)-2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl-1-phosphate
CAS No.:850883-58-8
Molecular Formula:C₂₅H₂₄FN₂O₉P
Molecular Weight:546.446
Hs Code.:

Synonyms:bis(2-cyanoethyl)-2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl-1-phosphate

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Chemical Property of bis(2-cyanoethyl)-2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl-1-phosphate

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Technology Process of bis(2-cyanoethyl)-2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl-1-phosphate

There total 2 articles about bis(2-cyanoethyl)-2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl-1-phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 109-78-4
3-Hydroxypropionitrile

: 850883-58-8
bis(2-cyanoethyl)-2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl-1-phosphate

Guidance literature:: 3,5-bis-O-benzoyl-2-deoxy-2-fluoro-α-D-arabinofuranose; With bis(diisopropylamino)chlorophosphine; triethylamine; In acetonitrile; at 20 ℃; for 1h;

3-Hydroxypropionitrile; With 1H-tetrazole; In acetonitrile; at 20 ℃; for 1.5h;

With tert.-butylhydroperoxide; In acetonitrile; at 20 ℃; for 0.5h;

Reference yield:

: C₂₅H₂₄FN₂O₈P

: 850883-58-8
bis(2-cyanoethyl)-2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl-1-phosphate

Guidance literature:: With tert.-butylhydroperoxide; In acetonitrile; for 0.5h;
DOI:10.1080/15257770903396741

Reference yield: 89.0%

: 850883-58-8
bis(2-cyanoethyl)-2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl-1-phosphate

: 850883-53-3
2-deoxy-3,5-di-O-benzoyl-2-fluoro-α-D-arabinofuranosyl-1-phosphate

Guidance literature:: bis(2-cyanoethyl)-2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl-1-phosphate; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 0.166667h;

With chloro-trimethyl-silane; In dichloromethane; at 20 ℃; for 1h;

With hydrogenchloride; In chloroform; water; Product distribution / selectivity;