5'-O-(tert-butyldiphenylsilyl)-2'-O-(methylsulfonyl)-β-D-arabinofuranosyladenine

Base Information

Chemical Name:5'-O-(tert-butyldiphenylsilyl)-2'-O-(methylsulfonyl)-β-D-arabinofuranosyladenine
CAS No.:219618-77-6
Molecular Formula:C₂₇H₃₃N₅O₆SSi
Molecular Weight:583.74
Hs Code.:

Synonyms:5'-O-(tert-butyldiphenylsilyl)-2'-O-(methylsulfonyl)-β-D-arabinofuranosyladenine

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Chemical Property of 5'-O-(tert-butyldiphenylsilyl)-2'-O-(methylsulfonyl)-β-D-arabinofuranosyladenine

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Technology Process of 5'-O-(tert-butyldiphenylsilyl)-2'-O-(methylsulfonyl)-β-D-arabinofuranosyladenine

There total 3 articles about 5'-O-(tert-butyldiphenylsilyl)-2'-O-(methylsulfonyl)-β-D-arabinofuranosyladenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 68121-19-7
2'-O-(methylsulfonyl)-β-D-arabinofuranosyladenine

: 58479-61-1
tert-butylchlorodiphenylsilane

: 219618-77-6
5'-O-(tert-butyldiphenylsilyl)-2'-O-(methylsulfonyl)-β-D-arabinofuranosyladenine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 12h; Ambient temperature;
DOI:10.1021/jm980466g

Reference yield:

: 87792-02-7
9-[3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-1-β-D-arabinofuranosyl]adenine

: 219618-77-6
5'-O-(tert-butyldiphenylsilyl)-2'-O-(methylsulfonyl)-β-D-arabinofuranosyladenine

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N, DMAP / CH₂Cl₂ / 2 h / 0 °C

2: TBAF / tetrahydrofuran / 2 h / 0 °C

3: 85 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

With 1H-imidazole; dmap; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980466g

Reference yield:

: 154534-78-8
Methanesulfonic acid (2R,3S,3aR,9aR)-2-(6-amino-purin-9-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester

: 219618-77-6
5'-O-(tert-butyldiphenylsilyl)-2'-O-(methylsulfonyl)-β-D-arabinofuranosyladenine

Guidance literature:: Multi-step reaction with 2 steps

1: TBAF / tetrahydrofuran / 2 h / 0 °C

2: 85 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

With 1H-imidazole; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm980466g