(2E,5E,7E)-(4R,9S)-9-Methoxy-2,4,7-trimethyl-11-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-undeca-2,5,7-trienoic acid

Base Information

• Chemical Name: (2E,5E,7E)-(4R,9S)-9-Methoxy-2,4,7-trimethyl-11-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-undeca-2,5,7-trienoic acid
• CAS No.: 914375-09-0
• Molecular Formula: C₂₂H₂₈N₄O₃S
• Molecular Weight: 428.555
• Mol file: 914375-09-0.mol

Synonyms:(2E,5E,7E)-(4R,9S)-9-Methoxy-2,4,7-trimethyl-11-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-undeca-2,5,7-trienoic acid

Chemical Property of (2E,5E,7E)-(4R,9S)-9-Methoxy-2,4,7-trimethyl-11-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-undeca-2,5,7-trienoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E,5E,7E)-(4R,9S)-9-Methoxy-2,4,7-trimethyl-11-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-undeca-2,5,7-trienoic acid

There total 11 articles about (2E,5E,7E)-(4R,9S)-9-Methoxy-2,4,7-trimethyl-11-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-undeca-2,5,7-trienoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(2E,5E,7E)-(4R,9S)-9-Methoxy-2,4,7-trimethyl-11-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-undeca-2,5,7-trienoic acid ethyl ester (914374-79-1) → (2E,5E,7E)-(4R,9S)-9-Methoxy-2,4,7-trimethyl-11-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-undeca-2,5,7-trienoic acid (914375-09-0)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

DOI:10.1002/anie.200601859

Reference yield:

(E)-(S)-6-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-2-methyl-hex-2-enal (914374-73-5) → (2E,5E,7E)-(4R,9S)-9-Methoxy-2,4,7-trimethyl-11-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-undeca-2,5,7-trienoic acid (914375-09-0)

Guidance literature:

Multi-step reaction with 4 steps

1: NaHMDS / tetrahydrofuran / -78 - 20 °C

2: 60 percent / HCl / ethanol / 0 °C

3: 82 percent / DEAD; PPh₃ / tetrahydrofuran

4: 91 percent / aq. LiOH / tetrahydrofuran; methanol / 20 °C

With hydrogenchloride; lithium hydroxide; sodium hexamethyldisilazane; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol;

DOI:10.1002/anie.200601859

Reference yield:

(E)-(S)-5-(Benzothiazole-2-sulfonyl)-2,4-dimethyl-pent-2-enoic acid ethyl ester (914374-71-3) → (2E,5E,7E)-(4R,9S)-9-Methoxy-2,4,7-trimethyl-11-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-undeca-2,5,7-trienoic acid (914375-09-0)

Guidance literature:

Multi-step reaction with 4 steps

1: NaHMDS / tetrahydrofuran / -78 - 20 °C

2: 60 percent / HCl / ethanol / 0 °C

3: 82 percent / DEAD; PPh₃ / tetrahydrofuran

4: 91 percent / aq. LiOH / tetrahydrofuran; methanol / 20 °C

With hydrogenchloride; lithium hydroxide; sodium hexamethyldisilazane; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol;

DOI:10.1002/anie.200601859

upstream raw materials:

(2E,5E,7E)-(4R,9S)-9-Methoxy-2,4,7-trimethyl-11-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-undeca-2,5,7-trienoic acid ethyl ester

(E)-(S)-6-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-2-methyl-hex-2-enal

(2E,5E,7E)-(4R,9S)-11-Hydroxy-9-methoxy-2,4,7-trimethyl-undeca-2,5,7-trienoic acid ethyl ester

(E)-(S)-5-(Benzothiazole-2-sulfonyl)-2,4-dimethyl-pent-2-enoic acid ethyl ester