(S)-3-Amino-2-hydroxy-7-(3-methyl-ureido)-heptanoic acid ((R)-1-phenyl-ethyl)-amide

Base Information

Chemical Name:(S)-3-Amino-2-hydroxy-7-(3-methyl-ureido)-heptanoic acid ((R)-1-phenyl-ethyl)-amide
CAS No.:716329-37-2
Molecular Formula:C₁₇H₂₈N₄O₃
Molecular Weight:336.434
Hs Code.:

Synonyms:(S)-3-Amino-2-hydroxy-7-(3-methyl-ureido)-heptanoic acid ((R)-1-phenyl-ethyl)-amide

Suppliers and Price of (S)-3-Amino-2-hydroxy-7-(3-methyl-ureido)-heptanoic acid ((R)-1-phenyl-ethyl)-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-Amino-2-hydroxy-7-(3-methyl-ureido)-heptanoic acid ((R)-1-phenyl-ethyl)-amide

Chemical Property:

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Technology Process of (S)-3-Amino-2-hydroxy-7-(3-methyl-ureido)-heptanoic acid ((R)-1-phenyl-ethyl)-amide

There total 6 articles about (S)-3-Amino-2-hydroxy-7-(3-methyl-ureido)-heptanoic acid ((R)-1-phenyl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 568591-27-5
[(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-(3-methyl-ureido)-pentyl]-carbamic acid tert-butyl ester

: 716329-37-2
(S)-3-Amino-2-hydroxy-7-(3-methyl-ureido)-heptanoic acid ((R)-1-phenyl-ethyl)-amide

Guidance literature:: With hydrogenchloride; In ethyl acetate;
DOI:10.1016/j.bmcl.2004.02.085

Reference yield:

: 17329-20-3,21872-32-2,21872-33-3,42412-74-8
(R)-(+)-α-methylbenzylisocyanide

: 716329-37-2
(S)-3-Amino-2-hydroxy-7-(3-methyl-ureido)-heptanoic acid ((R)-1-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: CH₂Cl₂

2: aq. LiOH / dioxane / 100 °C

3: 99 percent / H₂ / Pd/C / ethanol / 2068.59 Torr

4: NEt₃ / tetrahydrofuran

5: 99 percent / HCl(g) / ethyl acetate / 0 °C

With hydrogenchloride; lithium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; 1: Passerini reaction;
DOI:10.1016/j.bmcl.2004.07.031

Reference yield:

: 82689-16-5
benzyl {(5S)-5-[(tert-butoxycarbonyl)amino]-6-oxohexyl}carbamate

: 716329-37-2
(S)-3-Amino-2-hydroxy-7-(3-methyl-ureido)-heptanoic acid ((R)-1-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: CH₂Cl₂

2: aq. LiOH / dioxane / 100 °C

3: 99 percent / H₂ / Pd/C / ethanol / 2068.59 Torr

4: NEt₃ / tetrahydrofuran

5: 99 percent / HCl(g) / ethyl acetate / 0 °C

With hydrogenchloride; lithium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; 1: Passerini reaction;
DOI:10.1016/j.bmcl.2004.07.031