<2R,3R,5S,6S,6(1S,2S)>-2,5-dimethoxy-6-<2-(benzyloxy)-1-methoxy-3-methylbutyl>-3-methyltetrahydropyran

Base Information

Chemical Name:<2R,3R,5S,6S,6(1S,2S)>-2,5-dimethoxy-6-<2-(benzyloxy)-1-methoxy-3-methylbutyl>-3-methyltetrahydropyran
CAS No.:136358-52-6
Molecular Formula:C₂₁H₃₄O₅
Molecular Weight:366.498
Hs Code.:

Synonyms:<2R,3R,5S,6S,6(1S,2S)>-2,5-dimethoxy-6-<2-(benzyloxy)-1-methoxy-3-methylbutyl>-3-methyltetrahydropyran

Suppliers and Price of <2R,3R,5S,6S,6(1S,2S)>-2,5-dimethoxy-6-<2-(benzyloxy)-1-methoxy-3-methylbutyl>-3-methyltetrahydropyran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of <2R,3R,5S,6S,6(1S,2S)>-2,5-dimethoxy-6-<2-(benzyloxy)-1-methoxy-3-methylbutyl>-3-methyltetrahydropyran

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of <2R,3R,5S,6S,6(1S,2S)>-2,5-dimethoxy-6-<2-(benzyloxy)-1-methoxy-3-methylbutyl>-3-methyltetrahydropyran

There total 10 articles about <2R,3R,5S,6S,6(1S,2S)>-2,5-dimethoxy-6-<2-(benzyloxy)-1-methoxy-3-methylbutyl>-3-methyltetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 116185-66-1,136457-98-2
(1R,2R,S,4R)-5-(benzyloxy)-1-(2,2-pentamethylene-1,3-dioxolan-4-yl)-2-methoxy-4-methylpentane

: 136358-52-6
<2R,3R,5S,6S,6(1S,2S)>-2,5-dimethoxy-6-<2-(benzyloxy)-1-methoxy-3-methylbutyl>-3-methyltetrahydropyran

Guidance literature:: Multi-step reaction with 10 steps

1: 57 percent / H₂ / 10percent Pd(OH)2/C / ethyl acetate; methanol / 16 h / Ambient temperature

2: oxalyl chloride/DMSO / CH₂Cl₂ / 0.75 h / -78 °C

3: Amberlyst-15 / 24 h / Ambient temperature

4: RuCl₃*3H₂O, NaIO₄ / CCl₄; acetonitrile; H₂O / 2 h / Ambient temperature

5: ethanol; diethyl ether

6: DIBAH / diethyl ether; hexane / 0.75 h / -78 °C

7: diethyl ether; hexane; tetrahydrofuran / 1 h / 0 °C

8: 1.) NaH / 1.) THF, RT, 60 min, 2.) THF, RT, 90 min

9: 1.) BH₃*THF, 2.) 1.0 N aq. NaOH, 30percent aq. H₂O₂ / 1.) THF, 0 deg C, 2.5 h, 2.) THF, RT, 90 min

10: 1.) KH / 1.) THF, from 0 deg C to RT, 95 min, 2.) THF, 30 min, RT

With ruthenium trichloride; sodium hydroxide; sodium periodate; amberlyst-15; borane-THF; oxalyl dichloride; hydrogen; dihydrogen peroxide; potassium hydride; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; palladium dihydroxide; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; ethanol; hexane; dichloromethane; water; ethyl acetate; acetonitrile;

Reference yield:

: 116185-65-0,116296-67-4,136457-94-8
(1R,2R,S,4R)-5-(benzyloxy)-1-(2,2-pentamethylene-1,3-dioxolan-4-yl)-4-methylpentan-2-ol

: 136358-52-6
<2R,3R,5S,6S,6(1S,2S)>-2,5-dimethoxy-6-<2-(benzyloxy)-1-methoxy-3-methylbutyl>-3-methyltetrahydropyran

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) NaH / 1.) DMSO, THF, RT, 90 min, 2.) DMSO, THF, RT, overnight

2: 57 percent / H₂ / 10percent Pd(OH)2/C / ethyl acetate; methanol / 16 h / Ambient temperature

3: oxalyl chloride/DMSO / CH₂Cl₂ / 0.75 h / -78 °C

4: Amberlyst-15 / 24 h / Ambient temperature

5: RuCl₃*3H₂O, NaIO₄ / CCl₄; acetonitrile; H₂O / 2 h / Ambient temperature

6: ethanol; diethyl ether

7: DIBAH / diethyl ether; hexane / 0.75 h / -78 °C

8: diethyl ether; hexane; tetrahydrofuran / 1 h / 0 °C

9: 1.) NaH / 1.) THF, RT, 60 min, 2.) THF, RT, 90 min

10: 1.) BH₃*THF, 2.) 1.0 N aq. NaOH, 30percent aq. H₂O₂ / 1.) THF, 0 deg C, 2.5 h, 2.) THF, RT, 90 min

11: 1.) KH / 1.) THF, from 0 deg C to RT, 95 min, 2.) THF, 30 min, RT

With ruthenium trichloride; sodium hydroxide; sodium periodate; amberlyst-15; borane-THF; oxalyl dichloride; hydrogen; dihydrogen peroxide; potassium hydride; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; palladium dihydroxide; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; ethanol; hexane; dichloromethane; water; ethyl acetate; acetonitrile;

Reference yield:

: 136358-33-3,136358-61-7
(2R,S,3R,5S,6R)-2,5-dimethoxy-6-(hydroxymethyl)-3-methyltetrahydropyran

: 136358-52-6
<2R,3R,5S,6S,6(1S,2S)>-2,5-dimethoxy-6-<2-(benzyloxy)-1-methoxy-3-methylbutyl>-3-methyltetrahydropyran

Guidance literature:: Multi-step reaction with 7 steps

1: RuCl₃*3H₂O, NaIO₄ / CCl₄; acetonitrile; H₂O / 2 h / Ambient temperature

2: ethanol; diethyl ether

3: DIBAH / diethyl ether; hexane / 0.75 h / -78 °C

4: diethyl ether; hexane; tetrahydrofuran / 1 h / 0 °C

5: 1.) NaH / 1.) THF, RT, 60 min, 2.) THF, RT, 90 min

6: 1.) BH₃*THF, 2.) 1.0 N aq. NaOH, 30percent aq. H₂O₂ / 1.) THF, 0 deg C, 2.5 h, 2.) THF, RT, 90 min

7: 1.) KH / 1.) THF, from 0 deg C to RT, 95 min, 2.) THF, 30 min, RT

With ruthenium trichloride; sodium hydroxide; sodium periodate; borane-THF; dihydrogen peroxide; potassium hydride; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol; hexane; water; acetonitrile;