diethyl N-{4-[2-(2,4-diaminopyrido[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate

Base Information

Chemical Name:diethyl N-{4-[2-(2,4-diaminopyrido[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate
CAS No.:381691-44-7
Molecular Formula:C₂₅H₃₀N₆O₅
Molecular Weight:494.55
Hs Code.:

Synonyms:diethyl N-{4-[2-(2,4-diaminopyrido[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate

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Chemical Property of diethyl N-{4-[2-(2,4-diaminopyrido[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate

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Technology Process of diethyl N-{4-[2-(2,4-diaminopyrido[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate

There total 4 articles about diethyl N-{4-[2-(2,4-diaminopyrido[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 4-[2-(2,4-diamino-pyrido[2,3-d]pyrimidin-5-yl)-ethyl]-benzoic acid

: 381691-44-7
diethyl N-{4-[2-(2,4-diaminopyrido[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate

Guidance literature:: 4-[2-(2,4-diamino-pyrido[2,3-d]pyrimidin-5-yl)-ethyl]-benzoic acid; With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In N,N-dimethyl-formamide; at 25 ℃; for 1h;

diethyl-L-glutamate hydrochloride; at 20 ℃; for 2h;
DOI:10.3987/com-01-9251

Reference yield:

: 381691-42-5
methyl 4-[2-(2-chloro-3-cyanopyrid-4-yl)ethyl]benzoate

: 381691-44-7
diethyl N-{4-[2-(2,4-diaminopyrido[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 54 percent / dimethylsulfoxide / 80 °C

2.1: aq. NaOH / methanol / 12 h / 20 °C

2.2: glacial AcOH

3.1: N-methylmorpholine; 6-chloro-2,4-dimethoxy-1,3,5-triazine / dimethylformamide / 1 h / 25 °C

3.2: 2 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.3987/com-01-9251

Reference yield:

: 381691-41-4
methyl 4-[4,4-dicyano-3-(2-dimethylaminovinyl)but-3-enyl]benzoate

: 381691-44-7
diethyl N-{4-[2-(2,4-diaminopyrido[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 94 percent / HCl gas / acetic acid / 20 °C

2.1: 54 percent / dimethylsulfoxide / 80 °C

3.1: aq. NaOH / methanol / 12 h / 20 °C

3.2: glacial AcOH

4.1: N-methylmorpholine; 6-chloro-2,4-dimethoxy-1,3,5-triazine / dimethylformamide / 1 h / 25 °C

4.2: 2 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In methanol; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.3987/com-01-9251