2-(2,4,5-trifluoro-6-(pyridin-2-yl)-3-(trifluoromethyl)phenyl)benzoxazole

Base Information

• Chemical Name: 2-(2,4,5-trifluoro-6-(pyridin-2-yl)-3-(trifluoromethyl)phenyl)benzoxazole
• CAS No.: 1422200-39-2
• Molecular Formula: C₁₉H₈F₆N₂O
• Molecular Weight: 394.276

Synonyms:2-(2,4,5-trifluoro-6-(pyridin-2-yl)-3-(trifluoromethyl)phenyl)benzoxazole

Chemical Property of 2-(2,4,5-trifluoro-6-(pyridin-2-yl)-3-(trifluoromethyl)phenyl)benzoxazole

Chemical Property:

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Technology Process of 2-(2,4,5-trifluoro-6-(pyridin-2-yl)-3-(trifluoromethyl)phenyl)benzoxazole

There total 2 articles about 2-(2,4,5-trifluoro-6-(pyridin-2-yl)-3-(trifluoromethyl)phenyl)benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

benzoxazole (273-53-0,29791-96-6) + 2-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pyridine (1422200-17-6) → 2-(2,4,5-trifluoro-6-(pyridin-2-yl)-3-(trifluoromethyl)phenyl)benzoxazole (1422200-39-2)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); lithium 2-methylpropan-2-olate; o-phenylenebis(diphenylphosphine); In 5,5-dimethyl-1,3-cyclohexadiene; at 130 ℃; Inert atmosphere;

DOI:10.1021/ol303567t

Reference yield:

2-bromo-pyridine (109-04-6) + 1,2,4,5-tetrafluoro-3-(trifluoromethyl)benzene (651-80-9) → 2-(2,4,5-trifluoro-6-(pyridin-2-yl)-3-(trifluoromethyl)phenyl)benzoxazole (1422200-39-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,10-Phenanthroline; potassium phosphate; copper(l) iodide / N,N-dimethyl-formamide; 5,5-dimethyl-1,3-cyclohexadiene / 12 h / 120 °C

2: dichloro bis(acetonitrile) palladium(II); o-phenylenebis(diphenylphosphine); lithium 2-methylpropan-2-olate / 5,5-dimethyl-1,3-cyclohexadiene / 130 °C / Inert atmosphere

With dichloro bis(acetonitrile) palladium(II); potassium phosphate; copper(l) iodide; 1,10-Phenanthroline; lithium 2-methylpropan-2-olate; o-phenylenebis(diphenylphosphine); In 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide;

DOI:10.1021/ol303567t

upstream raw materials:

benzoxazole

2-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pyridine

2-bromo-pyridine

1,2,4,5-tetrafluoro-3-(trifluoromethyl)benzene

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