Biotin-[2-(2-pyridyldithio)ethylamide]

Base Information

• Chemical Name: Biotin-[2-(2-pyridyldithio)ethylamide]
• CAS No.: 112247-65-1
• Molecular Formula: C₁₇H₂₄N₄O₂S₃
• Molecular Weight: 412.601
• Hs Code.: 2936290000
• Mol file: 112247-65-1.mol

Synonyms:Biotin-[2-(pyridin-2-ylthio)ethylamide];5-[(3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-[2-(pyridin-2-yldisulphanyl)ethyl]pentanamide;[3aS-(3aα,4β,6aα)]-Hexahydro-2-oxo-N-[2-(2-pyridinyldithio)ethyl]-1H-thieno[3,4-d]iMidazole-4-pentanaMide

Chemical Property of Biotin-[2-(2-pyridyldithio)ethylamide]

Chemical Property:

• Melting Point: 177-183°C
• Refractive Index: 1.657
• Boiling Point: 739.2±60.0 °C(Predicted)
• PKA: 13.90±0.40(Predicted)
• PSA: 159.02000
• Density: 1.36±0.1 g/cm3(Predicted)
• LogP: 3.71240
• Storage Temp.: -20°C Freezer

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-[2-(2-Pyridyldithio)ethyl]biotinamide >97.0%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A sulfhydryl reactive biotinylaton reagent.

Technology Process of Biotin-[2-(2-pyridyldithio)ethylamide]

There total 4 articles about Biotin-[2-(2-pyridyldithio)ethylamide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(pyridin-2-yldisulfanyl)ethan-1-amine hydrochloride + biotin N-Hydroxysuccinimide ester (35013-72-0) → (+)-biotin N-2-(pyridin-2-yldisulfanyl)ethyl amide (112247-65-1)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide;

Reference yield: 47.0%

2-(2-(2-pyridinyl)disulfanyl)ethylamine (83578-21-6) + biotin N-Hydroxysuccinimide ester (35013-72-0) → (+)-biotin N-2-(pyridin-2-yldisulfanyl)ethyl amide (112247-65-1)

Guidance literature:

With triethylamine; In water; N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 3h;

DOI:10.1002/ejoc.201900740

Reference yield:

2,2'-dipyridyldisulphide (2127-03-9) → (+)-biotin N-2-(pyridin-2-yldisulfanyl)ethyl amide (112247-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 2.5 h / 20 °C / Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide; water; acetonitrile / 3 h / 20 °C

With triethylamine; In methanol; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/ejoc.201900740

upstream raw materials:

biotin

biotin N-Hydroxysuccinimide ester

2,2'-dipyridyldisulphide

2-(2-(2-pyridinyl)disulfanyl)ethylamine

Refernces

• 1、 -. "ANTIBODY CONJUGATES AND METHODS OF MAKING THE ANTIBODY CONJUGATES". . . Retrieved 2017/01/02.