Technology Process of (1R,2R)-2-((benzyloxy)methyl)cyclopropanecarbaldehyde
There total 11 articles about (1R,2R)-2-((benzyloxy)methyl)cyclopropanecarbaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
at -78 ℃;
for 1.5h;
DOI:10.1021/jo030019v
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 95.5 percent / copper(I) iodide / tetrahydrofuran / -78 - 0 °C
2: 99 percent / imidazole / dimethylformamide / 20 °C
3: 85 percent / Grubb's catalyst / CH2Cl2 / Heating
4: tetrahydrofuran / 0.25 h
5: 2,6-lutidine; Tf2O / CH2Cl2 / 0.08 h / -78 °C
6: OsO4; NaIO4
With
1H-imidazole; 2,6-dimethylpyridine; sodium periodate; copper(l) iodide; osmium(VIII) oxide; trifluoromethylsulfonic anhydride;
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0037163
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 99 percent / imidazole / dimethylformamide / 20 °C
2: 85 percent / Grubb's catalyst / CH2Cl2 / Heating
3: tetrahydrofuran / 0.25 h
4: 2,6-lutidine; Tf2O / CH2Cl2 / 0.08 h / -78 °C
5: OsO4; NaIO4
With
1H-imidazole; 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; trifluoromethylsulfonic anhydride;
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0037163
