4-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)-6-methylpyridin-2(1H)-one

Base Information

Chemical Name:4-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)-6-methylpyridin-2(1H)-one
CAS No.:1416332-47-2
Molecular Formula:C₂₀H₂₉NO₃Si
Molecular Weight:359.541
Hs Code.:

Synonyms:4-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)-6-methylpyridin-2(1H)-one

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Chemical Property of 4-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)-6-methylpyridin-2(1H)-one

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Technology Process of 4-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)-6-methylpyridin-2(1H)-one

There total 6 articles about 4-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)-6-methylpyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1416332-40-5
(E)-4-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)but-3-en-2-one

: 49639-34-1,90617-28-0
phenylsulfinylacetic acid amide

: 1416332-47-2
4-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)-6-methylpyridin-2(1H)-one

Guidance literature:: (E)-4-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)but-3-en-2-one; phenylsulfinylacetic acid amide; With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In acetonitrile; at 50 ℃; for 4h; Inert atmosphere;

With acetic acid; In acetonitrile; for 3h; Inert atmosphere; Reflux;
DOI:10.1021/ol500162b

Reference yield:

: 20511-03-9,22214-29-5
4-(3’-hydroxyphenyl)-3(E)-buten-2-one

: 1416332-47-2
4-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)-6-methylpyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: tetra-(n-butyl)ammonium iodide; potassium carbonate / dimethyl sulfoxide / 5 h / 100 °C / Inert atmosphere

2: 1H-imidazole / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

3: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 4 h / 50 °C / Inert atmosphere

4: acetic acid / acetonitrile / Inert atmosphere; Reflux

5: acetic acid / acetonitrile / Inert atmosphere; Reflux

With 1H-imidazole; tetra-(n-butyl)ammonium iodide; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol303320c

Reference yield:

: 1416332-52-9
(E)-4-(3-(2-hydroxyethoxy)phenyl)but-3-en-2-one

: 1416332-47-2
4-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)-6-methylpyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 4 h / 50 °C / Inert atmosphere

3: acetic acid / acetonitrile / Inert atmosphere; Reflux

4: acetic acid / acetonitrile / Inert atmosphere; Reflux

With 1H-imidazole; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol303320c