1,3-Diazabicyclo[3.2.0]hept-3-ene-2-carboxylicacid,4-methyl-7-oxo-,cis-(9CI)

Base Information

Chemical Name:1,3-Diazabicyclo[3.2.0]hept-3-ene-2-carboxylicacid,4-methyl-7-oxo-,cis-(9CI)
CAS No.:112213-49-7
Molecular Formula:C₇H₈N₂O₃
Molecular Weight:168.152
Hs Code.:
Mol file:112213-49-7.mol

Synonyms:1,3-Diazabicyclo[3.2.0]hept-3-ene-2-carboxylicacid, 4-methyl-7-oxo-, cis- (9CI);1,3-Diazabicyclo[3.2.0]hept-3-ene-2-carboxylic acid, 4-methyl-7-oxo-, cis-(?à)-

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,3-Diazabicyclo[3.2.0]hept-3-ene-2-carboxylicacid,4-methyl-7-oxo-,cis-(9CI)

Chemical Property:

Boiling Point:426.1±45.0 °C(Predicted)
PKA:1.47±0.40(Predicted)
PSA：69.97000
Density:1.77±0.1 g/cm3(Predicted)
LogP:-1.15400

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,3-Diazabicyclo[3.2.0]hept-3-ene-2-carboxylicacid,4-methyl-7-oxo-,cis-(9CI)

There total 5 articles about 1,3-Diazabicyclo[3.2.0]hept-3-ene-2-carboxylicacid,4-methyl-7-oxo-,cis-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 79669-37-7,79669-38-8,80282-23-1,80282-24-2
(2RS,5RS)-benzyl 4-methyl-7-oxo-1,3-diazabicyclo<3.2.0>hept-3-ene-carboxylate

: 112213-49-7
(2RS,5RS)-4-methyl-7-oxo-1,3-diazabicyclo<3.2.0>hept-3-ene-carboxylic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 1.5h;

Reference yield:

: 79669-45-7
1-4-vinylazetidin-2-one

: 112213-49-7
(2RS,5RS)-4-methyl-7-oxo-1,3-diazabicyclo<3.2.0>hept-3-ene-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide / dimethylformamide / 1 h / Ambient temperature

2: 23 percent / toluene / 31 h

3: 50 percent / DBU / CH₂Cl₂ / 1.67 h / -20 °C

4: 87 percent / H₂ / 10percent Pd-C / tetrahydrofuran / 1.5 h

With sodium azide; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 79669-44-6
1--4-vinylazetidin-2-one

: 112213-49-7
(2RS,5RS)-4-methyl-7-oxo-1,3-diazabicyclo<3.2.0>hept-3-ene-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride, 2,6-dimethylpyridine / tetrahydrofuran / 0.17 h / -20 °C

2: sodium azide / dimethylformamide / 1 h / Ambient temperature

3: 23 percent / toluene / 31 h

4: 50 percent / DBU / CH₂Cl₂ / 1.67 h / -20 °C

5: 87 percent / H₂ / 10percent Pd-C / tetrahydrofuran / 1.5 h

With 2,6-dimethylpyridine; thionyl chloride; sodium azide; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;