2-(4-BROMO-PHENOXY)-PROPYLAMINE

Base Information

• Chemical Name: 2-(4-BROMO-PHENOXY)-PROPYLAMINE
• CAS No.: 886763-33-3
• Molecular Formula: C₉H₁₂BrNO
• Molecular Weight: 230.104
• Mol file: 886763-33-3.mol

Synonyms:2-(4-bromophenoxy)propylamine

Chemical Property of 2-(4-BROMO-PHENOXY)-PROPYLAMINE

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

1-[(1-Aminopropan-2-yl)oxy]-4-bromobenzene 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-BROMO-PHENOXY)-PROPYLAMINE

There total 3 articles about 2-(4-BROMO-PHENOXY)-PROPYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-bromophenoxy)propanamide (360791-98-6) → 2-(4-bromophenoxy)propylamine (886763-33-3)

Guidance literature:

2-(4-bromophenoxy)propanamide; With boranemethylsulfide; In tetrahydrofuran; at 70 ℃; Heating / reflux;

With sodium hydroxide; In tetrahydrofuran; methanol; for 5h; Heating / reflux;

Reference yield:

4-bromo-phenol (106-41-2) → 2-(4-bromophenoxy)propylamine (886763-33-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: DMF (N,N-dimethyl-formamide) / 0.75 h / 20 °C

1.2: 3 h / 80 °C

2.1: ammonia / tetrahydrofuran; methanol / 48 h / 20 °C

3.1: boranemethylsulfide / tetrahydrofuran / 70 °C / Heating / reflux

3.2: 5 h / Heating / reflux

With boranemethylsulfide; ammonia; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide);

Reference yield:

methyl 2-(4-bromophenoxy)propanoate (23849-12-9) → 2-(4-bromophenoxy)propylamine (886763-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonia / tetrahydrofuran; methanol / 48 h / 20 °C

2.1: boranemethylsulfide / tetrahydrofuran / 70 °C / Heating / reflux

2.2: 5 h / Heating / reflux

With boranemethylsulfide; ammonia; In tetrahydrofuran; methanol;

upstream raw materials:

2-(4-bromophenoxy)propanamide

4-bromo-phenol

methyl 2-(4-bromophenoxy)propanoate

Refernces