2,4-diamino-5-(3',5'-dimethoxy-4'-methylbenzyl)pyrimidine hydrochloride

Base Information

Chemical Name:2,4-diamino-5-(3',5'-dimethoxy-4'-methylbenzyl)pyrimidine hydrochloride
CAS No.:78025-95-3
Molecular Formula:C₁₄H₁₈N₄O₂*ClH
Molecular Weight:310.783
Hs Code.:

Synonyms:2,4-diamino-5-(3',5'-dimethoxy-4'-methylbenzyl)pyrimidine hydrochloride

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Chemical Property of 2,4-diamino-5-(3',5'-dimethoxy-4'-methylbenzyl)pyrimidine hydrochloride

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Technology Process of 2,4-diamino-5-(3',5'-dimethoxy-4'-methylbenzyl)pyrimidine hydrochloride

There total 5 articles about 2,4-diamino-5-(3',5'-dimethoxy-4'-methylbenzyl)pyrimidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78025-94-2
4-cyano-2,6-dimethoxytoluene

: 78025-95-3
2,4-diamino-5-(3',5'-dimethoxy-4'-methylbenzyl)pyrimidine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / 90percent formic acid / Raney Ni / H₂O / 6 h / Heating

2: t-BuOK / 2-methyl-propan-2-ol; dimethylsulfoxide / 1.5 h / 55 - 60 °C

3: NaOMe / ethanol / 24 h / Heating

With formic acid; potassium tert-butylate; sodium methylate; nickel; In ethanol; water; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1021/jm00140a005

Reference yield:

: 22794-95-2
1-bromo-2,4-dimethoxy-3-methylbenzene

: 78025-95-3
2,4-diamino-5-(3',5'-dimethoxy-4'-methylbenzyl)pyrimidine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / K, NH₃(liquid), Fe(NO₃)3 / 3 h

2: 1.) HNO₂, 2.) Cu₂(CN)2, NaCN / 1.) 0 deg C, 2.) a) H₂O, toluene, 0 deg C, 30 min, b) 60 deg C, 1 h

3: 45 percent / 90percent formic acid / Raney Ni / H₂O / 6 h / Heating

4: t-BuOK / 2-methyl-propan-2-ol; dimethylsulfoxide / 1.5 h / 55 - 60 °C

5: NaOMe / ethanol / 24 h / Heating

With formic acid; Cu₂(CN)2; sodium cyanide; potassium tert-butylate; ammonia; sodium methylate; cis-nitrous acid; ferric nitrate; nickel; In ethanol; water; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1021/jm00140a005

Reference yield:

: 78025-93-1
3,5-dimethoxy-4-methylaniline

: 78025-95-3
2,4-diamino-5-(3',5'-dimethoxy-4'-methylbenzyl)pyrimidine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) HNO₂, 2.) Cu₂(CN)2, NaCN / 1.) 0 deg C, 2.) a) H₂O, toluene, 0 deg C, 30 min, b) 60 deg C, 1 h

2: 45 percent / 90percent formic acid / Raney Ni / H₂O / 6 h / Heating

3: t-BuOK / 2-methyl-propan-2-ol; dimethylsulfoxide / 1.5 h / 55 - 60 °C

4: NaOMe / ethanol / 24 h / Heating

With formic acid; Cu₂(CN)2; sodium cyanide; potassium tert-butylate; sodium methylate; cis-nitrous acid; nickel; In ethanol; water; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1021/jm00140a005