S-tert-butyl (2R,3S)-3-(4-bromophenyl)-2-methyl-3-(4-methylphenylsulfonamido)propanethioate

Base Information

• Chemical Name: S-tert-butyl (2R,3S)-3-(4-bromophenyl)-2-methyl-3-(4-methylphenylsulfonamido)propanethioate
• CAS No.: 1323421-38-0
• Molecular Formula: C₂₁H₂₆BrNO₃S₂
• Molecular Weight: 484.478
• Mol file: 1323421-38-0.mol

Synonyms:S-tert-butyl (2R,3S)-3-(4-bromophenyl)-2-methyl-3-(4-methylphenylsulfonamido)propanethioate

Chemical Property of S-tert-butyl (2R,3S)-3-(4-bromophenyl)-2-methyl-3-(4-methylphenylsulfonamido)propanethioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-tert-butyl (2R,3S)-3-(4-bromophenyl)-2-methyl-3-(4-methylphenylsulfonamido)propanethioate

There total 1 articles about S-tert-butyl (2R,3S)-3-(4-bromophenyl)-2-methyl-3-(4-methylphenylsulfonamido)propanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3-(tert-butylthio)-2-methyl-3-oxopropanoic acid (1323420-98-9) + N-(4-bromobenzylidene)-4-methylbenzenesulfonamide (36176-90-6) → S-tert-butyl (2S,3S)-3-(4-bromophenyl)-2-methyl-3-(4-methylphenylsulfonamido)propanethioate (1323421-46-0) + S-tert-butyl (2R,3S)-3-(4-bromophenyl)-2-methyl-3-(4-methylphenylsulfonamido)propanethioate (1323421-38-0) + S-tert-butyl (2R,3R)-3-(4-bromophenyl)-2-methyl-3-(4-methylphenylsulfonamido)propanethioate

Guidance literature:

N-(4-bromobenzylidene)-4-methylbenzenesulfonamide; With 2,6-di-tert-butyl-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazole; In tert-butyl methyl ether; at 20 ℃; for 0.166667h;

3-(tert-butylthio)-2-methyl-3-oxopropanoic acid; In tert-butyl methyl ether; at 20 ℃; for 96h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/chem.201100687

upstream raw materials:

3-(tert-butylthio)-2-methyl-3-oxopropanoic acid

N-(4-bromobenzylidene)-4-methylbenzenesulfonamide