7-cyclobutyl-4-(4'-(ethylsulfonyl)-2',6-difluoro-[1,1'-biphenyl]-3-yl)-7H-imidazo[4,5-c]pyridazine

Base Information

Chemical Name:7-cyclobutyl-4-(4'-(ethylsulfonyl)-2',6-difluoro-[1,1'-biphenyl]-3-yl)-7H-imidazo[4,5-c]pyridazine
CAS No.:1614245-92-9
Molecular Formula:C₂₃H₂₀F₂N₄O₂S
Molecular Weight:454.5
Hs Code.:

Synonyms:7-cyclobutyl-4-(4'-(ethylsulfonyl)-2',6-difluoro-[1,1'-biphenyl]-3-yl)-7H-imidazo[4,5-c]pyridazine

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Chemical Property of 7-cyclobutyl-4-(4'-(ethylsulfonyl)-2',6-difluoro-[1,1'-biphenyl]-3-yl)-7H-imidazo[4,5-c]pyridazine

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Technology Process of 7-cyclobutyl-4-(4'-(ethylsulfonyl)-2',6-difluoro-[1,1'-biphenyl]-3-yl)-7H-imidazo[4,5-c]pyridazine

There total 7 articles about 7-cyclobutyl-4-(4'-(ethylsulfonyl)-2',6-difluoro-[1,1'-biphenyl]-3-yl)-7H-imidazo[4,5-c]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1614246-58-0
2-[4'-(ethylsulfonyl)-2',6-difluorobiphenyl-3-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1614246-98-8
4-chloro-7-cyclobutyl-7H-imidazo[4,5-c]pyridazine

: 1614245-92-9
7-cyclobutyl-4-(4'-(ethylsulfonyl)-2',6-difluoro-[1,1'-biphenyl]-3-yl)-7H-imidazo[4,5-c]pyridazine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 80 ℃; for 18h; Inert atmosphere;

Reference yield:

: 351003-51-5
4-bromo-3-fluorobenzene-1-sulfonyl chloride

: 1614245-92-9
7-cyclobutyl-4-(4'-(ethylsulfonyl)-2',6-difluoro-[1,1'-biphenyl]-3-yl)-7H-imidazo[4,5-c]pyridazine

Guidance literature:: Multi-step reaction with 6 steps

1: hydrazine hydrate / 4.75 h / 0 - 20 °C

2: sodium acetate / ethanol / 18 h / Reflux

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 16.5 h / 90 °C / Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 2 h / 80 °C

5: potassium acetate; palladium diacetate; XPhos / 1,4-dioxane / 20 h / 110 °C / Sealed tube

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 18 h / 80 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium acetate; palladium diacetate; sodium carbonate; hydrazine hydrate; XPhos; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide;

Reference yield:

: 779329-61-2
1-bromo-4-(ethylsulfonyl)-2-fluorobenzene

: 1614245-92-9
7-cyclobutyl-4-(4'-(ethylsulfonyl)-2',6-difluoro-[1,1'-biphenyl]-3-yl)-7H-imidazo[4,5-c]pyridazine

Guidance literature:: Multi-step reaction with 4 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 16.5 h / 90 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 2 h / 80 °C

3: potassium acetate; palladium diacetate; XPhos / 1,4-dioxane / 20 h / 110 °C / Sealed tube

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 18 h / 80 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; palladium diacetate; sodium carbonate; XPhos; In 1,4-dioxane; water; dimethyl sulfoxide;