(E)-4-[2-(4-chlorophenyl)vinyl]-2-(4-methoxyphenyl)furo[3,2-c]quinoline

Base Information

Chemical Name:(E)-4-[2-(4-chlorophenyl)vinyl]-2-(4-methoxyphenyl)furo[3,2-c]quinoline
CAS No.:1619235-57-2
Molecular Formula:C₂₆H₁₈ClNO₂
Molecular Weight:411.887
Hs Code.:

Synonyms:(E)-4-[2-(4-chlorophenyl)vinyl]-2-(4-methoxyphenyl)furo[3,2-c]quinoline

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Chemical Property of (E)-4-[2-(4-chlorophenyl)vinyl]-2-(4-methoxyphenyl)furo[3,2-c]quinoline

Chemical Property:

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Technology Process of (E)-4-[2-(4-chlorophenyl)vinyl]-2-(4-methoxyphenyl)furo[3,2-c]quinoline

There total 6 articles about (E)-4-[2-(4-chlorophenyl)vinyl]-2-(4-methoxyphenyl)furo[3,2-c]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1619235-51-6
(E,E)-2-[2-(4-chlorophenyl)vinyl]-3-[2-(4-methoxyphenyl)vinyl]quinolin-4(1H)-one

: 1619235-54-9
3-(4-chlorophenyl)-2-(4-methoxyphenyl)acridin-9(10H)-one

: 1619235-57-2
(E)-4-[2-(4-chlorophenyl)vinyl]-2-(4-methoxyphenyl)furo[3,2-c]quinoline

Guidance literature:: With iodine; toluene-4-sulfonic acid; Reflux; Inert atmosphere;
DOI:10.1016/j.tet.2014.05.040

Reference yield:

: 1093768-14-9
C₁₇H₁₂ClNO

: 1619235-54-9
3-(4-chlorophenyl)-2-(4-methoxyphenyl)acridin-9(10H)-one

: 1619235-57-2
(E)-4-[2-(4-chlorophenyl)vinyl]-2-(4-methoxyphenyl)furo[3,2-c]quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: iodine; sodium carbonate / tetrahydrofuran / 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / acetonitrile / 5 h / Inert atmosphere; Reflux

3: iodine; toluene-4-sulfonic acid / Reflux; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; sodium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; acetonitrile; 2: |Heck Reaction;
DOI:10.1016/j.tet.2014.05.040

Reference yield:

: 1260427-67-5
(E)-2-[2-(4-chlorophenyl)vinyl]-3-iodoquinolin-4(1H)-one

: 1619235-54-9
3-(4-chlorophenyl)-2-(4-methoxyphenyl)acridin-9(10H)-one

: 1619235-57-2
(E)-4-[2-(4-chlorophenyl)vinyl]-2-(4-methoxyphenyl)furo[3,2-c]quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / acetonitrile / 5 h / Inert atmosphere; Reflux

2: iodine; toluene-4-sulfonic acid / Reflux; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; toluene-4-sulfonic acid; triethylamine; In acetonitrile; 1: |Heck Reaction;
DOI:10.1016/j.tet.2014.05.040