N-{3-[N'-(2,7-di-tert-butyl-9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-4-methoxy-phenyl}-oxalamic acid

Base Information

• Chemical Name: N-{3-[N'-(2,7-di-tert-butyl-9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-4-methoxy-phenyl}-oxalamic acid
• CAS No.: 295800-33-8
• Molecular Formula: C₃₃H₃₇N₃O₇
• Molecular Weight: 587.673
• Mol file: 295800-33-8.mol

Synonyms:N-{3-[N'-(2,7-di-tert-butyl-9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-4-methoxy-phenyl}-oxalamic acid

Chemical Property of N-{3-[N'-(2,7-di-tert-butyl-9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-4-methoxy-phenyl}-oxalamic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{3-[N'-(2,7-di-tert-butyl-9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-4-methoxy-phenyl}-oxalamic acid

There total 6 articles about N-{3-[N'-(2,7-di-tert-butyl-9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-4-methoxy-phenyl}-oxalamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-{3-[N'-(2,7-di-tert-butyl-9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-4-methoxy-phenyl}-oxalamic acid ethyl ester (295800-32-7) → N-{3-[N'-(2,7-di-tert-butyl-9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-4-methoxy-phenyl}-oxalamic acid (295800-33-8)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; for 0.5h;

DOI:10.1021/ja001142w

Reference yield:

2-methoxy-5-nitrobenzoic acid (40751-89-1) → N-{3-[N'-(2,7-di-tert-butyl-9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-4-methoxy-phenyl}-oxalamic acid (295800-33-8)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / CH₂Cl₂ / 0.5 h

2: H₂ / 10percent Pd/C / methanol; tetrahydrofuran / 2 h

3: 99 percent / pyridine / CH₂Cl₂ / 0.25 h / 0 °C

4: 99 percent / aq. NaOH / tetrahydrofuran / 0.5 h

With pyridine; sodium hydroxide; hydrogen; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane; 1: Acylation / 2: Reduction / 3: Acylation / 4: Hydrolysis;

DOI:10.1021/ja001142w

Reference yield:

2,7-di-tert-butyl-9-fluorenylmethoxycarbonyl chloride (287381-46-8) → N-{3-[N'-(2,7-di-tert-butyl-9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-4-methoxy-phenyl}-oxalamic acid (295800-33-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / hydrazine / diethyl ether / 3 h

2: pyridine / CH₂Cl₂ / 0.5 h

3: H₂ / 10percent Pd/C / methanol; tetrahydrofuran / 2 h

4: 99 percent / pyridine / CH₂Cl₂ / 0.25 h / 0 °C

5: 99 percent / aq. NaOH / tetrahydrofuran / 0.5 h

With pyridine; sodium hydroxide; hydrogen; hydrazine; 10percent Pd/C; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1: Acylation / 2: Acylation / 3: Reduction / 4: Acylation / 5: Hydrolysis;

DOI:10.1021/ja001142w

upstream raw materials:

N-{3-[N'-(2,7-di-tert-butyl-9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-4-methoxy-phenyl}-oxalamic acid ethyl ester

2-methoxy-5-nitrobenzoic acid

2,7-di-tert-butyl-9-fluorenylmethoxycarbonyl chloride

N'-(2-methoxy-5-nitro-benzoyl)-hydrazinecarboxylic acid 2,7-di-tert-butyl-9H-fluoren-9-ylmethyl ester