Proline, 5-ethenyl-, ethyl ester, cis- (9CI)

Base Information

• Chemical Name: Proline, 5-ethenyl-, ethyl ester, cis- (9CI)
• CAS No.: 112009-96-8
• Molecular Formula: C₉H₁₅NO₂
• Molecular Weight: 169.224
• Mol file: 112009-96-8.mol

Synonyms:Proline, 5-ethenyl-, ethyl ester, cis- (9CI)

Chemical Property of Proline, 5-ethenyl-, ethyl ester, cis- (9CI)

Chemical Property:

• Boiling Point: 219.0±40.0 °C(Predicted)
• PKA: 7.86±0.10(Predicted)
• PSA: 0.00000
• Density: 1.059±0.06 g/cm3(Predicted)
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Proline, 5-ethenyl-, ethyl ester, cis- (9CI)

There total 6 articles about Proline, 5-ethenyl-, ethyl ester, cis- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-aminohepta-5,6-dienoate (112009-92-4) → cis-5-vinylproline ethyl ester (112009-96-8,112009-97-9,133099-28-2,133099-30-6)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂

2: 88 percent / AgBF₄ / CH₂Cl₂ / 72 h / Ambient temperature

3: CF₃CO₂H / CH₂Cl₂ / Ambient temperature

With trifluoroacetic acid; silver tetrafluoroborate; In dichloromethane;

Reference yield:

ethyl 2-benzylideneaminohepta-5,6-dienoate (112009-90-2) → cis-5-vinylproline ethyl ester (112009-96-8,112009-97-9,133099-28-2,133099-30-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 59 percent / aq. HCl / diethyl ether / 0.67 h / Ambient temperature

2: CH₂Cl₂

3: 88 percent / AgBF₄ / CH₂Cl₂ / 72 h / Ambient temperature

4: CF₃CO₂H / CH₂Cl₂ / Ambient temperature

With hydrogenchloride; trifluoroacetic acid; silver tetrafluoroborate; In diethyl ether; dichloromethane;

Reference yield:

ethyl 2-(methoxycarbonylamino)hepta-5,6-dienoate (133038-46-7) → cis-5-vinylproline ethyl ester (112009-96-8,112009-97-9,133099-28-2,133099-30-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / AgBF₄ / CH₂Cl₂ / 65 h / Ambient temperature

2: NaI, (CH₃)3SiCl / acetonitrile / 2 h / Heating

With chloro-trimethyl-silane; sodium iodide; silver tetrafluoroborate; In dichloromethane; acetonitrile;

upstream raw materials:

cis-1-methoxycarbonyl-5-vinylproline ethyl ester

cis-1-(t-butoxycarbonyl)-5-vinylproline ethyl ester

ethyl 2-aminohepta-5,6-dienoate

ethyl 2-(methoxycarbonylamino)hepta-5,6-dienoate

Downstream raw materials:

cis-1-(p-tolylsulphonyl)-5-vinylproline

cis 2-(2-bromoethyl)-5-<(methylsulphonyl)acetyl>-1-(p-tolylsulphonyl)pyrrolidine

cis-2-(2-hydroxyethyl)-1-(p-tolylsulphonyl)-5-<(methylsulphonyl)acetyl>pyrrolidine

3-(methylsulphonyl)-9-(p-tolylsulphonyl)-9-azabicyclo<4.2.1>nonan-2-one

Refernces