(S)-5-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)pent-1-ynyl)-1-methylpyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:(S)-5-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)pent-1-ynyl)-1-methylpyrimidine-2,4(1H,3H)-dione
CAS No.:1380423-88-0
Molecular Formula:C₃₂H₄₄N₂O₄Si₂
Molecular Weight:576.883
Hs Code.:

Synonyms:(S)-5-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)pent-1-ynyl)-1-methylpyrimidine-2,4(1H,3H)-dione

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Chemical Property of (S)-5-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)pent-1-ynyl)-1-methylpyrimidine-2,4(1H,3H)-dione

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Technology Process of (S)-5-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)pent-1-ynyl)-1-methylpyrimidine-2,4(1H,3H)-dione

There total 5 articles about (S)-5-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)pent-1-ynyl)-1-methylpyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1380423-87-9
(S)-2,2,3,3,9,9-hexamethyl-8,8-diphenyl-5-(prop-2-ynyl)-4,7-dioxa-3,8-disiladecane

: 45774-47-8
5-iodo-1-methyluracil

: 1380423-88-0
(S)-5-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)pent-1-ynyl)-1-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; at 40 ℃; for 24h;
DOI:10.1016/j.bmcl.2015.04.034

Reference yield:

: 895153-57-8
(S)-1-(tert-butyldiphenylsilyloxy)-5-(trimethylsilyl)pent-4-yn-2-ol

: 1380423-88-0
(S)-5-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)pent-1-ynyl)-1-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / Inert atmosphere

1.2: Inert atmosphere

2.1: methanol; sodium methylate / methanol / 1 h / 20 °C / Inert atmosphere

3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 40 °C

With 1H-imidazole; methanol; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; triethylamine; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1380423-88-0
(S)-5-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)pent-1-ynyl)-1-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide

1.2: 0 °C

2.1: n-butyllithium; boron trifluoride diethyl etherate / tetrahydrofuran / -78 °C / Inert atmosphere

3.1: 1H-imidazole / N,N-dimethyl-formamide / Inert atmosphere

3.2: Inert atmosphere

4.1: methanol; sodium methylate / methanol / 1 h / 20 °C / Inert atmosphere

5.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 40 °C

With 1H-imidazole; methanol; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; boron trifluoride diethyl etherate; sodium methylate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;