methyl 4-(3-isopropoxy-4-methoxyphenyl)-5-(4-isopropoxy-3-methoxyphenyl)-1H-pyrrole-2-carboxylate

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Chemical Name:methyl 4-(3-isopropoxy-4-methoxyphenyl)-5-(4-isopropoxy-3-methoxyphenyl)-1H-pyrrole-2-carboxylate
CAS No.:1519002-15-3
Molecular Formula:C₂₆H₃₁NO₆
Molecular Weight:453.535
Hs Code.:

Synonyms:methyl 4-(3-isopropoxy-4-methoxyphenyl)-5-(4-isopropoxy-3-methoxyphenyl)-1H-pyrrole-2-carboxylate

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Chemical Property of methyl 4-(3-isopropoxy-4-methoxyphenyl)-5-(4-isopropoxy-3-methoxyphenyl)-1H-pyrrole-2-carboxylate

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Technology Process of methyl 4-(3-isopropoxy-4-methoxyphenyl)-5-(4-isopropoxy-3-methoxyphenyl)-1H-pyrrole-2-carboxylate

There total 3 articles about methyl 4-(3-isopropoxy-4-methoxyphenyl)-5-(4-isopropoxy-3-methoxyphenyl)-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1519002-14-2
methyl 4-bromo-5-(4-isopropoxy-3-methoxyphenyl)-1H-pyrrole-2-carboxylate

: 516465-82-0
(3-isopropoxy-4-methoxyphenyl)boronic acid

: 1519002-15-3
methyl 4-(3-isopropoxy-4-methoxyphenyl)-5-(4-isopropoxy-3-methoxyphenyl)-1H-pyrrole-2-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; for 18h; Inert atmosphere; Reflux;
DOI:10.1021/jo402181w

Reference yield:

: 924708-81-6
methyl 5-bromo-1-(tert-butoxycarbonyl)-1H-pyrrole-2-carboxylate

: 1519002-15-3
methyl 4-(3-isopropoxy-4-methoxyphenyl)-5-(4-isopropoxy-3-methoxyphenyl)-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 21.5 h / Inert atmosphere; Reflux

1.2: 19 h / Reflux

2.1: N-Bromosuccinimide / tetrahydrofuran / 18 h / -78 - 0 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 18 h / Inert atmosphere; Reflux

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1.1: |Suzuki-Miyaura Coupling / 3.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jo402181w

Reference yield:

: 1519002-13-1
methyl 5-(4-isopropoxy-3-methoxyphenyl)-1H-pyrrole-2-carboxylate

: 1519002-15-3
methyl 4-(3-isopropoxy-4-methoxyphenyl)-5-(4-isopropoxy-3-methoxyphenyl)-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide / tetrahydrofuran / 18 h / -78 - 0 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 18 h / Inert atmosphere; Reflux

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water; 2: |Suzuki-Miyaura Coupling;
DOI:10.1021/jo402181w