N-[3-fluoro-4-((1-[(4-methylphenyl)sulfonyl]-3-vinyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl]-acetamide

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Chemical Name:N-[3-fluoro-4-((1-[(4-methylphenyl)sulfonyl]-3-vinyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl]-acetamide
CAS No.:867018-08-4
Molecular Formula:C₂₄H₂₀FN₃O₄S
Molecular Weight:465.505
Hs Code.:

Synonyms:N-[3-fluoro-4-((1-[(4-methylphenyl)sulfonyl]-3-vinyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl]-acetamide

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Chemical Property of N-[3-fluoro-4-((1-[(4-methylphenyl)sulfonyl]-3-vinyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl]-acetamide

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Technology Process of N-[3-fluoro-4-((1-[(4-methylphenyl)sulfonyl]-3-vinyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl]-acetamide

There total 1 articles about N-[3-fluoro-4-((1-[(4-methylphenyl)sulfonyl]-3-vinyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 855863-43-3
N-[4-({3-bromo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}oxy)-3-fluorophenyl]-acetamide

: 6336-45-4
vinylboronic acid dibutyl ester

: 867018-08-4
N-[3-fluoro-4-((1-[(4-methylphenyl)sulfonyl]-3-vinyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl]-acetamide

Guidance literature:: N-[4-({3-bromo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}oxy)-3-fluorophenyl]-acetamide; With potassium carbonate; In DMF (N,N-dimethyl-formamide);

vinylboronic acid dibutyl ester; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In DMF (N,N-dimethyl-formamide); at 90 ℃; for 3h;

Reference yield: 73.0%

: 867018-08-4
N-[3-fluoro-4-((1-[(4-methylphenyl)sulfonyl]-3-vinyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl]-acetamide

: 867018-09-5
N-[4-({3-ethyl-l-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}oxy)-3-fluorophenyl]-acetamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; under 1140.08 Torr;

Reference yield: 51.0%

: 867018-08-4
N-[3-fluoro-4-((1-[(4-methylphenyl)sulfonyl]-3-vinyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl]-acetamide

: 867018-11-9
N-[3-fluoro-4-({3-(2-hydroxyethyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}oxy)phenyl]-acetamide

Guidance literature:: N-[3-fluoro-4-((1-[(4-methylphenyl)sulfonyl]-3-vinyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl]-acetamide; With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 20 - 60 ℃; for 1h;