13-cyclohexyl-10-[[((dimethylamino)sulfonyl)amino]carbonyl]-3-methoxy-7H-indolo[2,1a][2]benzazepine-6-carboxylic acid

Base Information

Chemical Name:13-cyclohexyl-10-[[((dimethylamino)sulfonyl)amino]carbonyl]-3-methoxy-7H-indolo[2,1a][2]benzazepine-6-carboxylic acid
CAS No.:902148-42-9
Molecular Formula:C₂₈H₃₁N₃O₆S
Molecular Weight:537.637
Hs Code.:

Synonyms:13-cyclohexyl-10-[[((dimethylamino)sulfonyl)amino]carbonyl]-3-methoxy-7H-indolo[2,1a][2]benzazepine-6-carboxylic acid

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Chemical Property of 13-cyclohexyl-10-[[((dimethylamino)sulfonyl)amino]carbonyl]-3-methoxy-7H-indolo[2,1a][2]benzazepine-6-carboxylic acid

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Technology Process of 13-cyclohexyl-10-[[((dimethylamino)sulfonyl)amino]carbonyl]-3-methoxy-7H-indolo[2,1a][2]benzazepine-6-carboxylic acid

There total 13 articles about 13-cyclohexyl-10-[[((dimethylamino)sulfonyl)amino]carbonyl]-3-methoxy-7H-indolo[2,1a][2]benzazepine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 902148-54-3
13-cyclohexyl-10-[[[(dimethylamino)sulfonyl]amino]carbonyl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylic acid methyl ester

: 902148-42-9
13-cyclohexyl-10-[[((dimethylamino)sulfonyl)amino]carbonyl]-3-methoxy-7H-indolo[2,1a][2]benzazepine-6-carboxylic acid

Guidance literature:: 13-cyclohexyl-10-[[[(dimethylamino)sulfonyl]amino]carbonyl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylic acid methyl ester; With methanol; sodium hydroxide; water; In tetrahydrofuran; at 85 ℃; for 0.5h; Microwave irradiation;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield:

: 1670-82-2,261352-47-0
Indole-6-carboxylic acid

: 902148-42-9
13-cyclohexyl-10-[[((dimethylamino)sulfonyl)amino]carbonyl]-3-methoxy-7H-indolo[2,1a][2]benzazepine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium methylate / methanol / 18.16 h / 22 °C / Heating / reflux

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 18 h / 20 °C / 2844.39 Torr

3.1: thionyl chloride / 18 h / Heating / reflux

4.1: pyridinium hydrobromide perbromide / tetrahydrofuran; chloroform / 2 - 2.66 h / 0 - 20 °C

5.1: methanol; lithium hydroxide; water / tetrahydrofuran / 2 - 3 h / 90 °C

5.2: 1 h / 0 - 20 °C

6.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 - 2.16 h / 22 - 50 °C

6.2: 21 - 24 h / 20 - 30 °C

7.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 20.42 h / 70 °C

8.1: hydrogenchloride; water / tetrahydrofuran / 16 h / 20 °C

9.1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 55 °C

10.1: methanol; sodium hydroxide; water / tetrahydrofuran / 0.5 h / 85 °C / microwave irradiation

With hydrogenchloride; methanol; lithium hydroxide; sodium hydroxide; thionyl chloride; water; hydrogen; sodium methylate; sodium carbonate; caesium carbonate; pyridinium hydrobromide perbromide; 1,1'-carbonyldiimidazole; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 902148-42-9
13-cyclohexyl-10-[[((dimethylamino)sulfonyl)amino]carbonyl]-3-methoxy-7H-indolo[2,1a][2]benzazepine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium methylate / methanol / 18.16 h / 22 °C / Heating / reflux

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 18 h / 20 °C / 2844.39 Torr

3.1: thionyl chloride / 18 h / Heating / reflux

4.1: pyridinium hydrobromide perbromide / tetrahydrofuran; chloroform / 2 - 2.66 h / 0 - 20 °C

5.1: methanol; lithium hydroxide; water / tetrahydrofuran / 2 - 3 h / 90 °C

5.2: 1 h / 0 - 20 °C

6.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 - 2.16 h / 22 - 50 °C

6.2: 21 - 24 h / 20 - 30 °C

7.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 20.42 h / 70 °C

8.1: hydrogenchloride; water / tetrahydrofuran / 16 h / 20 °C

9.1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 55 °C

10.1: methanol; sodium hydroxide; water / tetrahydrofuran / 0.5 h / 85 °C / microwave irradiation

With hydrogenchloride; methanol; lithium hydroxide; sodium hydroxide; thionyl chloride; water; hydrogen; sodium methylate; sodium carbonate; caesium carbonate; pyridinium hydrobromide perbromide; 1,1'-carbonyldiimidazole; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; toluene;