1-(2,3-didehydro-2,3-dideoxy-5-O-dimethoxytrityl-3-C-trifluoromethyl-β-D-glycero-pentofuranosyl)uracil

Base Information

Chemical Name:1-(2,3-didehydro-2,3-dideoxy-5-O-dimethoxytrityl-3-C-trifluoromethyl-β-D-glycero-pentofuranosyl)uracil
CAS No.:262289-34-9
Molecular Formula:C₃₁H₂₇F₃N₂O₆
Molecular Weight:580.56
Hs Code.:

Synonyms:1-(2,3-didehydro-2,3-dideoxy-5-O-dimethoxytrityl-3-C-trifluoromethyl-β-D-glycero-pentofuranosyl)uracil

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Chemical Property of 1-(2,3-didehydro-2,3-dideoxy-5-O-dimethoxytrityl-3-C-trifluoromethyl-β-D-glycero-pentofuranosyl)uracil

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Technology Process of 1-(2,3-didehydro-2,3-dideoxy-5-O-dimethoxytrityl-3-C-trifluoromethyl-β-D-glycero-pentofuranosyl)uracil

There total 3 articles about 1-(2,3-didehydro-2,3-dideoxy-5-O-dimethoxytrityl-3-C-trifluoromethyl-β-D-glycero-pentofuranosyl)uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 262289-33-8
3'-deoxy-3'-difluoromethylene-5'-O-dimethoxytrityl-2'-O-trimethylsilylethoxymethyluridine

: 262289-34-9
1-(2,3-didehydro-2,3-dideoxy-5-O-dimethoxytrityl-3-C-trifluoromethyl-β-D-glycero-pentofuranosyl)uracil

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 50 ℃; for 3h;
DOI:10.1016/S0040-4020(99)01007-8

Reference yield:

: 159755-13-2
5'-O-dimethoxytrityl-2'-O-trimethylsilylethoxymethyluridine

: 262289-34-9
1-(2,3-didehydro-2,3-dideoxy-5-O-dimethoxytrityl-3-C-trifluoromethyl-β-D-glycero-pentofuranosyl)uracil

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin periodinane / CH₂Cl₂ / 0 - 20 °C

2: 0.39 g / zinc / tetrahydrofuran / 0.42 h / Heating

3: 70 percent / tetrabutylammonium fluoride / tetrahydrofuran / 3 h / 50 °C

With tetrabutyl ammonium fluoride; Dess-Martin periodane; zinc; In tetrahydrofuran; dichloromethane; 1: Oxidation / 2: Substitution / 3: Fluorination;
DOI:10.1016/S0040-4020(99)01007-8

Reference yield:

: 262289-32-7
5'-O-dimethoxytrityl-3'-oxo-2'-O-trimethylsilylethoxymethyluridine

: 262289-34-9
1-(2,3-didehydro-2,3-dideoxy-5-O-dimethoxytrityl-3-C-trifluoromethyl-β-D-glycero-pentofuranosyl)uracil

Guidance literature:: Multi-step reaction with 2 steps

1: 0.39 g / zinc / tetrahydrofuran / 0.42 h / Heating

2: 70 percent / tetrabutylammonium fluoride / tetrahydrofuran / 3 h / 50 °C

With tetrabutyl ammonium fluoride; zinc; In tetrahydrofuran; 1: Substitution / 2: Fluorination;
DOI:10.1016/S0040-4020(99)01007-8